Effects of bacterial products on enterocyte-macrophage interactions in vitro

► Human blood monocytes cocultured with Caco-2 cells develop intestinal macrophage phenotype. ► LPS and MDP induce monocyte migration into cultures. ► LPS and MDP differentially affect secretion of inflammatory cytokines in cocultures. ► Monocyte/caco2 model has potential to study intestinal inflammatory processes.