Key residues for the oligomerization of Aβ42 protein in Alzheimer's disease

► Aβ oligomers are neurotoxins and likely the causing agents for Alzheimer's disease. ► Aβ42 fusion protein form globular oligomers. ► Aβ42 fusion protein oligomers contain SDS-resistant tetramers and hexamers. ► Cysteine substitutions at residues 31, 32, 34, 39-41 disrupt Aβ42 oligomerization.