Glutathione-S-transferase pi 1(GSTP1) gene silencing in prostate cancer cells is reversed by the histone deacetylase inhibitor depsipeptide

► Depsipeptide induces apoptosis in prostate cancer cells. ► Hypermethylated GSTP1 promoter is associated with repressive histone pattern. ► Depsipeptide reverses DNA methylation and reduces repressive histone modifications. ► Depsipeptide induces GSTP1 re-expression.