Solution structure of a short-chain insecticidal toxin LaIT1 from the venom of scorpion Liocheles australasiae

► Solution structure of a scorpion insecticidal toxin LaIT1 is determined. ► LaIT1 exhibits a new class of inhibitory cystine knot (ICK)-like fold. ► LaIT1 has no sequence similarity to all the other known ICK-fold peptides. ► Two arginine residues are important to the insecticidal activity of LaIT1.