Ibuprofen and warfarin modulate allosterically ferrous human serum heme-albumin nitrosylation

► Human serum heme-albumin displays globin-like properties. ► Nitrosylation of ferrous human serum heme-albumin. ► Allosteric modulation of ferrous human serum heme-albumin nitrosylation. ► Ibuprofen and warfarin are allosteric effectors of human serum albumin. ► Human serum albumin could be the prototype of monomeric allosteric proteins.