Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization

► Two anticancer agents PDT and/or LCL85 affect distinctly the sphingolipid profile. ► PDT/LCL85 induces enhanced autophagy, caspase-3 activation, without cell death. ► Long-term exposure to PDT/LCL85 leads to enhanced total cell killing.