PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins

► Polycomb repressive complex (PRC) 2 is critical to transcription repression. ► PRC2 subunits are unstable and degraded by the ubiquitin-proteasome system. ► PRC2 degradation may have implications to transcriptional regulation and development. ► PRAJA1 is a ubiquitin ligase of PRC2 subunits.