Keywords: Histone methylation; Histone demethylation; Lung cancer; Histone methyltransferase; Histone demethylase; Inhibitors; ALK; anaplastic lymphoma kinase; DUSP3; dual-specificity phosphatase 3; Elk1; ETS-domain containing protein; EMT; epithelial-to-mesenchyma
مقالات ISI (ترجمه نشده)
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Keywords: ChEA; Chip-Enrichment Analysis; DEGs; differentially expressed gene; DE-TFs; differentially expressed TFs; ECs; epithelial-like cells; iNs; induced neurons; iNSCs; induced neural stem cells; NRPCs; neural restricted progenitor cells; NSCs; neural stem cel
Keywords: CT; computed tomography; IV; intravenous; PET; Positron Emission Tomography; Gy; gray; PRC2; polycomb repressive complex 2; Myoepithelial carcinoma; Epithelioid sarcoma; SMARCB1 deficiency; EZH2 inhibitor; Case report;
Keywords: ACVR1; Activin A receptor type1; ATRX; A-thalassemia/mental retardation syndrome X-linked; BMP; Bone morphogenetic protein; BRAF; v-Raf murine sarcoma viral oncogene homolog B; CNS; Central nervous system; DAXX; Death domain-associated protein; DNMT; DNA
Keywords: ADA2; Adenosine deaminase 2; ASH1L; Absent, Small, or Homeotic 1-like; BAF; BRG1 associated factor; BAH; Bromoadjacent homology; BAZ2A; Bromodomain adjacent to zinc finger domain protein 2A; BET; Bromodomain and Extra-Terminal domain; BRPF1; Bromodomain a
Keywords: CAPRI; Ca2+-promoted RAS inactivator; CRMP-2; collapsin response mediator protein-2; CSRD; cysteine/serine-rich domain; CTD; C-terminal domain; ERK; extracellular signal-regulated kinase; FTI; farnesyltransferase inhibitor; FAK1; focal adhesion kinase 1;
Keywords: Polycomb; Epigenetic regulation; PRC1; PRC2;
Keywords: 5-aza-CdR; 5-aza-2â²-deoxycytidine; AML; acute myeloid leukemia; ANRIL; antisense non-coding RNA in the INK4 locus; CBP; CREB-binding protein; CDKN2A; Cyclin-Dependent Kinase Inhibitor 2A; CoREST; co-repressor for element-1-silencing transcription factor
Keywords: AID/APOBEC; activation-induced cytidine deaminase/apolipoprotein B mRNA-editing enzyme complex; BDNF; brain-derived neurotrophic factor; 5caC; 5-carboxylcytosine; CBP; CREB binding protein; CREB; cAMP response binding protein; DNMT; DNA methyltransferases
Keywords: α-KG; alpha-ketoglutarate; 2-HG; 2-hydroxyglutarate; 5hmC; 5-hydroxymethylcytosine; 5mC; 5-methylcytosine; AML; acute myeloid leukemia; ASXL1; additional sex combs-like 1; AZA; azacytidine; CMML; chronic myelomonocytic leukemia; DAC; decitabine; DNMT3A;
Keywords: lncRNA; long/large noncoding RNA; Xist; X-inactive specific transcript; mESC; mouse embryonic stem cell; Evf2; embryonic ventral forebrain 2; Six3os; sine oculis-related homeobox 3 homolog, opposite strand; Dlx1as; distal-less homeobox 1, antisense; EGO;
Keywords: PRC1; PRC2; Neurogenesis; Mouse; Human;
LncRNA HOXA-AS2 and its molecular mechanisms in human cancer
Keywords: lncRNA; HOXA-AS2; Diagnosis; Therapeutic target; Prognosis; APL; Acute promyelocytic leukemia; ATRA; All trans retinoic acid; Bax; BCL2-Associated X; BC; Breast cancer; Bcl-2; B-cell lymphoma-2; c-Myc; MYC proto-oncogene; CRC; Colorectal cancer; DDIT3; DN
EZH2 regulates dental pulp inflammation by direct effect on inflammatory factors
Keywords: EZH2; enhancer of zeste homolog 2; HDPCs; human dental pulp cells; ChIP; chromatin immunoprecipitation; PRC2; polycomb repressor complex 2; DZNep; 3-deazaneplanocin A; MAPK; mitogen-activated protein kinases; EZH2; Dental pulp inflammation; Inflammatory f
microRNA-124a suppresses PHF19 over-expression, EZH2 hyper-activation, and aberrant cell proliferation in human glioma
Keywords: Glioma; EZH2; PRC2; PHF19; miR-124a;
Structural insight into the role of VAL1 B3 domain for targeting to FLC locus in Arabidopsis thaliana
Keywords: Vernalization; Flowering; FLC locus; PRC2; B3 domain; DNA binding;
Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis
Keywords: carnosol (PubChem CID:442009); resveratrol (PubChem CID:445154); DZNep; 3-Deazaneplanoci A; ALT; alanine aminotransferase; AST; aspartate aminotransferase; CS; carnosol; CCl4; carbon tetrachloride; H3K27me3; catalyzes trimethylation of lysine 27 on histon
Polymorphisms in non-coding RNAs and risk of colorectal cancer: A systematic review and meta-analysis
Keywords: SNP; single nucleotide polymorphism; HOTAIR; HOX transcript antisense RNA; PRC2; polycomb repressive complex 2; H3K27; 27th amino acid in Histone H3; LncRNAs; long non-coding RNAs; PFS; progression-free survival; TTP; thrombotic thrombocytopenic purpura;
MicroRNA-26a is a key regulon that inhibits progression and metastasis of c-Myc/EZH2 double high advanced hepatocellular carcinoma
Keywords: c-Myc/EZH2 double positive; microRNA-26a; Epigenetics modification; Metastasis; Advanced hepatocellular carcinoma; AAV; adeno-associated virus; CDK8; cyclin dependent kinase 8; CTDSP2; CTD small phosphatase 2; DEN; diethylnitrosamine; DZNep; 3-deazaneplan
Regulation of plant height in rice by the Polycomb group genes OsEMF2b, OsFIE2 and OsCLF
Keywords: Plant height; PRC2; Cell expansion; Cell division; Plant hormones;
HSF1, in association with MORC2, downregulates ArgBP2 via the PRC2 family in gastric cancer cells
Keywords: HSF1; PRC2; Methylation; ArgBP2; Gastric cancer;
Interactions between microRNAs and long non-coding RNAs in cardiac development and repair
Keywords: AAV; adeno-associated virus; AMI; acute myocardial infarction; APF; autophagy promoting factor; Bvht; Braveheart; CARL/Carl; cardiac apoptosis-related lncRNA; CARMEN/Carmen; cardiac mesoderm enhancer-associated non-coding RNA; CHAER/Chaer; cardiac-hypertr
Chromatin organization regulated by EZH2-mediated H3K27me3 is required for OPN-induced migration of bone marrow-derived mesenchymal stem cells
Keywords: Osteopontin; Bone marrow-derived mesenchymal stem cells (BMSCs); Migration; Chromatin; Nuclear mechanics; ERK1/2 signalling; AFM; atomic force microscopy; BMSCs; bone marrow-derived mesenchymal stem cells; BSA; bovine serum albumin; CSK buffer; cytoskelet
Dual Role of EZH2 in Cutaneous Anaplastic Large Cell Lymphoma: Promoting Tumor Cell Survival and Regulating Tumor Microenvironment
Keywords: CD30+LPD; CD30+ lymphoproliferative disease; CTCL; cutaneous T-cell lymphoma; CXCL10; C-X-C motif chemokine ligand 10; CXCR3; C-X-C motif chemokine receptor 3; EZH2; enhancer of zeste homolog; H3K27me3; histone H3 lysine 27 trimethylation; LCT; large-cell
YAP promotes breast cancer metastasis by repressing growth differentiation factor-15
Keywords: ALPP; alkaline phosphatase; AREG; amphiregulin; α-SMA; alpha smooth muscle actin; BIRC5; baculoviral inhibitor of apoptosis repeat-containing 5; ChIP; chromatin immunoprecipitation; CTGF; connective tissue growth factor; DDIT4; DNA-damage inducible trans
HOTAIR-mediated reciprocal regulation of EZH2 and DNMT1 contribute to polyphyllin I-inhibited growth of castration-resistant prostate cancer cells in vitro and in vivo
Keywords: PPI; polyphyllin I; CRPC; castration-resistant prostate cancer; EZH2; Zeste homolog 2; DNMT1; DNA methyltransferase 1; HOTAIR; HOX transcript antisense RNA; ADT; androgen deprivation therapy; NF-κB; nuclear factor-kappaB; lncRNA; Long non-coding RNA; DNM
BMI1 and PTEN are key determinants of breast cancer therapy: A plausible therapeutic target in breast cancer
Keywords: HDAC i; histone deacetylase inhibitors; PcG; polycomb group; PRC1; polycomb repressive complex 1; PRC2; polycomb repressive complex 2; Bmi1; B lymphoma Mo-MLV insertion region homolog; EMT; epithelial to mesenchymal transition; PTEN; phosphatase and tensi
Overexpression of dJmj differentially affects intestinal stem cells and differentiated enterocytes
Keywords: ISCs; intestinal stem cells; EBs; enteroblasts; ECs; enterocytes; EEs; enteroendocrine cells; PRC2; Polycomb repressive complex 2; H3K27me3; tri-methylation of lysine 27 of histone H3; Su(H); suppressor of hairless; Pdm1; POU-domain transcription factor;
EZH2-mediated α-actin methylation needs lncRNA TUG1, and promotes the cortex cytoskeleton formation in VSMCs
Keywords: LncRNAs; long non-coding RNAs; TUG1; taurine up-regulated gene 1; VSMCs; vascular smooth muscle cells; SENCR; smooth muscle and endothelial cell enriched migration/differentiation-associated long non-coding RNA; Ang II; angiotensin II; PRC2; polycomb repr
SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding
Keywords: PRC2; EED; Protein-protein interaction inhibitor (PPI); Cancer;
PRC2 during vertebrate organogenesis: A complex in transition
Keywords: Polycomb; Cell fate; Histone methyltransferase; Differentiation; PRC2; Epigenetics;
Split luciferase-based biosensors for characterizing EED binders
Keywords: PRC2; EED; H3K27me3-pocket; Split luciferase; Biosensor; EED[G255D]; EED; embryonic ectoderm development; PRC2; polycomb repressive complex 2; DSF; differential scanning fluorimetry; ITC; isothermal titration calorimetry; EZH2; enhancer of zeste homolog 2
Rice PcG gene OsEMF2b controls seed dormancy and seedling growth by regulating the expression of OsVP1
Keywords: Expression reprogramming; OsEMF2b; OsVP1/OsABI3; PRC2; Seed dormancy;
The Human Immunodeficiency Virus 1 ASP RNA promotes viral latency by recruiting the Polycomb Repressor Complex 2 and promoting nucleosome assembly
Keywords: HIV-1; Antisense transcript; ASP; Viral latency; PRC2; H3K27me3; Epigenetic marks;
Mini-reviewNaturally occurring anti-cancer agents targeting EZH2
Keywords: EZH2; Cancer; PRC2; Polycomb proteins; Natural compounds; Chemosensitization;
Histone methyltransferase SETDB1 maintains survival of mouse spermatogonial stem/progenitor cells via PTEN/AKT/FOXO1 pathway
Keywords: SETDB1; set domain, bifurcated 1; H3K9; histone H3 lysine 9; SSCs; spermatogonial stem cells; GDNF; glial cell line-derived neurotrophic factor; SFK; Src family kinase; PI3K; phosphatidylinositol 3-kinase; ESCs; embryo stem cells; DMEM/F12; Modified Eagle
Compositional and functional diversity of canonical PRC1 complexes in mammals
Keywords: bps; base pairs; PcG; Polycomb Group; PRC1; Polycomb Repressive Complex 1; PRC2; Polycomb Repressive Complex 2; Pc; Polycomb; Ph; Polyhomeotic; Psc; Posterior sex combs; Sce; Sex combs extra; H3K27me3; histone H3 lysine 27 trimethylation; SAM; sterile alp
EZH2 regulates spinal neuroinflammation in rats with neuropathic pain
Keywords: EDTA; ethylenediaminetetraacetic acid; EZH2; enhancer of zeste homolog-2; H3K27; histone H3 on K27; H3K27TM; tri-methylated H3K27; MeCP2; methyl-CpG-binding protein 2; PRC2; polycomb complex 2; pSNL; partial sciatic nerve ligation; nociception; cytokine;
Hotair facilitates hepatic stellate cells activation and fibrogenesis in the liver
Keywords: Hotair; LncRNA HOX transcript antisense RNA; HSCs; hepatic stellate cells; PRC2; polycomb repressive complex 2; H3K27me3; histone H3-lysine27; DNMT1; DNA methyltransferase 1; α-SMA; alpha smooth muscle actin; Col1a1; alpha1(1) collagen; NcRNA; non-coding
Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays
Keywords: EZH2; Epigenetics; PRC2; Computational drug design; Pharmacophore-based virtual screening
OsSET7, a homologue of ARABIDOPSIS TRITHORAX-RELATED protein that plays a role in grain elongation regulation in rice
Keywords: ATXR; ARABIDOPSIS TRITHORAX-RELATED; BiFC; Bimolecular Fluorescence Complementation; CDS; coding sequence; HKMT; Histone Lysine Methyltransferase; SET; Suppressor of variegation, Enhancer of zeste and Trithorax; PcG; Polycomb Group; PCNA; Proliferating Ce
MicroRNAs: New regulators of IL-22
Keywords: IL-22; interleukin-22; Th22; T helper 22 cell; Th1; T helper 1 cell; Th17; T helper 17 cell; NK22; natural killer 22; NKT; natural killer T cell; ILCs; innate lymphoid cells; RORγt; retinoid orphan receptor γt; STAT3; signal transducer and activator of
Steroid receptor RNA activator: Biologic function and role in disease
Keywords: AF-2; activation function-2; AR; androgen receptor; C/EBPα; ccaat-enhancer-binding protein α; CTCF; CCCTC-binding factor; Ddx5; DEAD box protein 5; ERα; estrogen receptor α; GR; glucocorticoid receptor; Hes1; hairy and enhancer of split-1; HP1γ; hete
EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes
Keywords: cccDNA; circular covalently closed DNA; EpCAM; epithelial cell adhesion molecule; EpICD; EpCAM intracellular domain; hCSCs; hepatic cancer stem cells; HBV; hepatitis B virus; HBc; hepatitis B virus core antigen; HCC; hepatocellular carcinoma; PRC2; polyco
Dissecting the Roles of Polycomb Repressive Complex 2 Subunits in the Control of Skin Development
Keywords: FACS; fluorescence-activated cell-sorting; Krt; keratin; PRC2; polycomb repressive complex 2; RT-qPCR; semiquantitative real-time PCR;
Long noncoding RNAs: Lessons from genomic imprinting
Keywords: lncRNA; long noncoding RNA; DMR; Differentially methylated region; ICR; Imprinting control region; PWS; Prader-Willi syndrome; AS; Angelmann syndrome; MEGs; Maternally expressed genes; TTS; Triplex target sites; TFO; Triplex forming oligo; IG-DMR; Inter
Discovery, design, and synthesis of indole-based EZH2 inhibitors
Keywords: EZH2; PRC2; Histone methyltransferase; Epigenetics; Pyridone
A new kinetochore component CENP-W interacts with the polycomb-group protein EZH2 to promote gene silencing
Keywords: PRC2; EZH2; CENP-W; Kinetochore; Gene silencing; Oncogene; PRC2; polycomb repressive complex 2; CENP-W; centromere protein W; EZH2; enhancer of zeste homolog 2; SUZ12; suppressor of zeste 12; CENP-T; centromere protein T; HDAC; histone deacetylase; HOXA9;
Non-coding RNAs in gastric cancer
Keywords: ncRNAs; non-coding RNAs; sncRNAs; small ncRNAs; lncRNAs; long ncRNAs; snoRNAs; small nucleolar RNAs; piRNAs; Piwi-associated RNAs; miRNAs; microRNAs; tiRNAs; transcription initiation RNAs; lincRNAs; long intergenic ncRNAs; GC; gastric cancer; nts; nucleot
Ezh2 maintains retinal progenitor proliferation, transcriptional integrity, and the timing of late differentiation
Keywords: Histone modification; Retina; Neurogenesis; Proliferation; PRC2;