کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10798943 | 1054211 | 2016 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Long noncoding RNAs: Lessons from genomic imprinting
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کلمات کلیدی
H3K9me3histone H3 lysine 27 acetylationMBD1IGNKSRPTFORNAPIIHistone H3 lysine 9 trimethylationH3K27acH3K4me2BWSPRC2IG-DMRTTSDnmt1DMRASOICRPWSlncRNARNA polymerase II - آرانای پلیمراز II Antisense oligonucleotides - oligonucleotide antisenseenhancer RNA - RNA تقویت کنندهnoncoding RNA - RNA غیر CodingeRNA - ارناEpigenetics - اپی ژنتیکDiD - دی دیCompeting endogenous RNA - رقابت RNA درونیES cells - سلول ESiPS cells - سلول های IPSInduced pluripotent stem cells - سلول های بنیادی پرتوان القاییEmbryonic stem cells - سلولهای بنیادی جنینیPrader–Willi syndrome - سندرم Prader-WilliceRNA - سینهLong noncoding RNA - طولانی RNA غیر کدرDifferentially methylated region - منطقه متخلخل متفاوتی داردGenomic imprinting - نشانه گذاری ژنومیhistone H3 lysine 4 trimethylation - هیستون H3 لیزین 4 trimethylationpolycomb repressive complex 2 - پیچک سرکوبگر پلی کامب 2Chromatin - کروماتینImprinting Control Region - کنترل ناحیه کنترل
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Genomic imprinting has been a great resource for studying transcriptional and post-transcriptional-based gene regulation by long noncoding RNAs (lncRNAs). In this article, I overview the functional role of intergenic lncRNAs (H19, IPW, and MEG3), antisense lncRNAs (Kcnq1ot1, Airn, Nespas, Ube3a-ATS), and enhancer lncRNAs (IG-DMR eRNAs) to understand the diverse mechanisms being employed by them in cis and/or trans to regulate the parent-of-origin-specific expression of target genes. Recent evidence suggests that some of the lncRNAs regulate imprinting by promoting intra-chromosomal higher-order chromatin compartmentalization, affecting replication timing and subnuclear positioning. Whereas others act via transcriptional occlusion or transcriptional collision-based mechanisms. By establishing genomic imprinting of target genes, the lncRNAs play a critical role in important biological functions, such as placental and embryonic growth, pluripotency maintenance, cell differentiation, and neural-related functions such as synaptic development and plasticity. An emerging consensus from the recent evidence is that the imprinted lncRNAs fine-tune gene expression of the protein-coding genes to maintain their dosage in cell. Hence, lncRNAs from imprinted clusters offer insights into their mode of action, and these mechanisms have been the basis for uncovering the mode of action of lncRNAs in several other biological contexts. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1859, Issue 1, January 2016, Pages 102-111
Journal: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms - Volume 1859, Issue 1, January 2016, Pages 102-111
نویسندگان
Chandrasekhar Kanduri,