کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8536935 | 1560923 | 2018 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular pathogenesis and therapeutic implications in pediatric high-grade gliomas
ترجمه فارسی عنوان
پاتوژنز مولکولی و پیامدهای درمانی در کودکان مبتلا به گلیوما درجه یک
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کلمات کلیدی
HGGenhancer of zeste 2 polycomb repressive complex 2 subunitSETD2ACVR1v-raf murine sarcoma viral oncogene homolog BPRC2DAXXEZH2TP53IDHBRAFPNETPDGFRAATRXDnmtHDACDNA methyltransferase - DNA متیل ترانسفرازMAPK - MAPKEpigenetics - اپی ژنتیکIsocitrate dehydrogenase - ایزوسیترات دهیدروژنازBrain tumor - تومور مغزیtumor protein p53 - تومور پروتئین p53Primitive neuroectodermal tumors - تومورهای اولیه نوروکتودرمالTargeted therapy - درمان هدفمندCNS - دستگاه عصبی مرکزیWorld Health Organization - سازمان بهداشت جهانیcentral nervous system - سیستم عصبی مرکزیBMP - مدیریت فرایند کسب و کارhistone deacetylase - هیستون داستیلازBone morphogenetic protein - پروتئین مورفوژنیک استخوانmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenplatelet derived growth factor receptor alpha - پلاکت عامل گیرنده عامل گیرنده آلفاpolycomb repressive complex 2 - پیچک سرکوبگر پلی کامب 2WHO - کهHigh-grade gliomas - گلیوما درجه بالا
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
چکیده انگلیسی
High-grade gliomas (HGG) are the most common malignant brain tumors in the pediatric population and account for a large subset of all pediatric central nervous system neoplasms. The management of pediatric HGG continues to be challenging, with poor outcome in many cases despite aggressive treatments. Consequently, parallel research efforts have been focused on identifying the underlying genetic and biological basis of pediatric HGG in order to more clearly define prognostic subgroups for treatment stratification as well as identify new treatment targets. These cutting-edge advances have revolutionized pediatric neuro-oncology and have revealed novel oncogenic vulnerabilities that are being therapeutically leveraged. Promising treatments - including pathway-targeting small molecules as well as epigenetic therapy - are being evaluated in clinical trials, and recent genomic discoveries in rare glioma subgroups have led to the identification of additional new potentially-actionable alterations. This review summarizes the current state of knowledge about the molecular characterization of pediatric HGG in correlation to the revised World Health Organization (WHO) classification, as well as provides an overview of some targeted treatment approaches in the modern clinical management of high-grade gliomas.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 182, February 2018, Pages 70-79
Journal: Pharmacology & Therapeutics - Volume 182, February 2018, Pages 70-79
نویسندگان
Tareq A. Juratli, Nan Qin, Daniel P. Cahill, Mariella G. Filbin,