Species differences of macrophage very low-density-lipoprotein (VLDL) receptor protein expression

► We discovered species differences in macrophage VLDL-R protein. ► Human and rabbit macrophage VLDL-R protein were detected, no mouse macrophage VLDL-R protein was detected in vitro and in vivo. ► Studies of VLDL-R signaling for TGRLs should focus on human or rabbit than mouse. ► The mechanisms of atherosclerotic lesions may be partly different among species.