Structural analysis of the intracellular domain of (pro)renin receptor fused to maltose-binding protein

► Crystal structure of the intracellular domain of (pro)renin receptor (PRR-IC) as MBP fusion protein at 2.0 Å (maltose-free) and 2.15 Å (maltose-bound). ► MBP fusion protein is a dimer in crystals in the presence and absence of maltose. ► PRR-IC domain is responsible for the dimerization of the fusion protein. ► Residues in the PRR-IC domain, particularly two tyrosines, dominate the intermolecular interactions, suggesting a role for the PRR-IC domain in PRR dimerization.