Keywords: دامنه درون سلولی; GHR; growth hormone receptor; GHRtm; recombinant fragment GHR254-294; JAK2; Janus kinase 2; RTK; receptor tyrosine kinase; TMD; transmembrane domain; ECD; extracellular domain; ICD; intracellular domain; JM; juxtamembrane; ecJM; extracellular juxtamembr
مقالات ISI دامنه درون سلولی (ترجمه نشده)
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Keywords: دامنه درون سلولی; RTK; receptor tyrosine kinase; TKL; tyrosine kinase-like receptor; GPI-AP; glycosylphosphatidylinositol-anchored protein; SH2; Scr homology 2 domain; TMD; transmembrane domain; ECD; extracellular domain or ectodomain; ICD; intracellular domain; JM; juxtam
Keywords: دامنه درون سلولی; BP; bitopic protein; RTK; receptor tyrosine kinase; TMD; transmembrane domain; JM; juxtamembrane; ECD; extracellular domain; ICD; intracellular domain; NMR; nuclear magnetic resonance; MD; molecular dynamics; LID; “ligand-induced dimerization” mechani
Keywords: دامنه درون سلولی; Tumor Stroma; Inflammation; Stomach Cancer; Tumor Cells; α-SMA; alpha-smooth muscle actin; CAFs; cancer-associated fibroblasts; CM; conditioned medium; DGC; diffuse-type gastric cancer; ECM; extracellular matrix; EMT; epithelial-to-mesenchymal transition
Keywords: دامنه درون سلولی; HCC; hepatocellular carcinoma; DDS; drug delivery system; ECM; extracellular matrix; MVD; microvessel density; EPR; enhanced permeability and retention; ASGP-R; asialoglycoprotein receptor; GPC3; glypican 3; HS chain; heparin sulfate chain; GA; glycyrrhet
Keywords: دامنه درون سلولی; FBS; fetal bovine serum; CTF; carboxyl-terminal fragment; ICD; intracellular domain; RIP; regulated intramembrane proteolysis; PS; presenilin; ADAM; a disintegrin and metalloprotease; TAPI; tumor necrosis factor-α protease inhibitor; TRAIL; TNF-related a
A modified clear-native polyacrylamide gel electrophoresis technique to investigate the oligomeric state of MBP-5-HT3A-intracellular domain chimeras
Keywords: دامنه درون سلولی; Clear-native PAGE; Multi-angle light scattering; Native gel electrophoresis; Protein oligomerization; Protein quaternary structures; Size exclusion chromatography; 5-HT3A; serotonin type 3A; 6-AHA; 6-aminohexanoic acid; BN-PAGE; blue-native polyacrylamide
Tyrosine kinase activity of EphA2 promotes its S897 phosphorylation and glioblastoma cell proliferation
Keywords: دامنه درون سلولی; EphA2; ERK; Cell proliferation; Glioblastoma; BrdU; bromodeoxyuridine; EGF; epidermal growth factor; ICD; intracellular domain; PI3K; phosphatidylinositol 3-kinase; PKA; protein kinase A; RSK; p90 ribosomal S6 kinase; RTK; receptor tyrosine kinase; S897;
Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB
Keywords: دامنه درون سلولی; ACh; acetylcholine; AChBP; acetylcholine-binding protein; ECD; extracellular domain; gAuIB; globular AuIB; ICD; intracellular domain; nAChR; nicotinic acetylcholine receptor; rAuIB; ribbon AuIB; SAR; structure-activity relationship; TMD; transmembrane dom
GLA supplementation regulates PHD2 mediated hypoxia and mitochondrial apoptosis in DMBA induced mammary gland carcinoma
Keywords: دامنه درون سلولی; AA; arachidonic acid; AB; alveolar bud; AAA; aromatic amino acid; BCAA; branched chain amino acid; BSA; bovine serum albumin; BMRB; biological magnetic resonance databank; CEC; cuboidal epithelial cell; CPMG; carr-purcell-meiboom-gill; DMBA; 7, 12-d
Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens
Keywords: دامنه درون سلولی; CKO; “conditional knock-out” allele; ICD; intracellular domain; NEXT; Notch extracellular truncation; PLE; presumptive lens ectoderm; AEL; anterior epithelial layer; E0.5; embryonic day 0.5; H&E; hematoxylin and eosin; OCT; optimal cutting temperature
Objective, domain-specific HER2 measurement in uterine and ovarian serous carcinomas and its clinical significance
Keywords: دامنه درون سلولی; HER2; Intracellular domain; Extracellular domain; Serous carcinoma; Quantitative immunofluorescence; Targeted therapy;
Regulation of Wnt signaling by protocadherins
Keywords: دامنه درون سلولی; Pcdhs; protocadherins; EC; extracellular cadherin; PP1a; protein phosphatase 1a; WIRS; WRC interacting receptor sequence; FAK; focal adhesion kinase; PKC; protein kinase C; MMTV; mouse mammary tumor virus; Fzd; frizzleds; ICD; intracellular domain; Dvls;
The roles of subcellularly located EGFR in autophagy
Keywords: دامنه درون سلولی; AMPK; AMP-activated protein kinase; ATG; autophagy-related; BCL2; B-cell lymphoma 2; BCL2L1; BCL2 like 1; BNIP3; BCL2/Adenovirus E1B-binding protein Nip3; CME; clathrin-mediated endocytosis; cytoSTAT3; cytoplasmic STAT3; Dsbs; double strand breaks; ECD; e
Posttranslational proteolytic processing of Leda-1/Pianp involves cleavage by MMPs, ADAM10/17 and gamma-secretase
Keywords: دامنه درون سلولی; Gamma secretase; Proteolysis; ADAM; Immune regulation; Nervous system; Leda-1; liver endothelial differentiation-associated protein-1; Pianp; PILR alpha associated neural protein; PILR; paired immunoglobin-like type 2 receptor; AJAP-1; adherens-junction-a
Simvastatin inhibits CD44 fragmentation in chondrocytes
Keywords: دامنه درون سلولی; Chondrocyte; Pericellular matrix; Statin; CD44; Lipid raft; ADAM10; HA; hyaluronan; OA; osteoarthritis; OSM; Oncostatin M; BAC; bovine articular chondrocytes; HAC; human articular chondrocytes; MT1-MMP; membrane type I metalloproteinase; ICD; intracellula
The multifaceted roles of the invariant chain CD74 - More than just a chaperone
Keywords: دامنه درون سلولی; ICD; intracellular domain; MHCII; MHC class II; MIF; macrophage migration inhibitory factor; NTF; N-terminal fragment; SPPL2a; Signal peptide peptidase-like 2a; Invariant chain; Antigen presentation; Intramembrane proteolysis; Endosomal trafficking; Macro
Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2
Keywords: دامنه درون سلولی; GPR64; GPCR; G protein; Molecular pharmacology; Signal transduction; Peptide agonist; 7TM; seven-transmembrane spanning domain; CTF; C-terminal fragment; ECD; extracellular domain; eV; empty vector; DMEM; dulbecco minimum essential medium; ELISA; enzyme-l
The positive is inside the negative: HER2-negative tumors can express the HER2 intracellular domain and present a HER2-positive phenotype
Keywords: دامنه درون سلولی; HER 2; human epidermal growth factor receptor 2; FISH; fluorescent in situ hybridization; ECD; extracellular domain of HER2; ICD; intracellular domain of HER2; LC-MS; label-free nanoscale mass spectrometry; Human epithelial growth factor receptor 2 (HER
Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells
Keywords: دامنه درون سلولی; CMA; chromosomal microarray analysis; ICD; intracellular domain; MHCII; MHC class II complex; NTF; N-terminal fragment; RIP; regulated intramembrane proteolysis; SPP; Signal peptide peptidase; SPPL; Signal-peptide-peptidase-like; Invariant chain; CD74; B
The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells
Keywords: دامنه درون سلولی; Aβ; amyloid beta; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; beta-site APP-cleaving enzyme 1; CuBD; copper binding domain; ICD; intracellular domain; PCa; prostate cancer; sAPPα; soluble APP alpha; sAPPβ; soluble APP beta; SDS-
Podoplanin is a substrate of presenilin-1/γ-secretase
Keywords: دامنه درون سلولی; PDPN; podoplanin; fl-PDPN; full-length PDPN; EC; extracellular; TM; transmembrane; CT; cytoplasmic; ERM; ezrin radixin moesin; CTF; C-terminal fragment; ICD; intracellular domain; PS; presenilin; MEF; mouse embryonic fibroblast; RIP; regulated intramembra
Furin processing dictates ectodomain shedding of human FAT1 cadherin
Keywords: دامنه درون سلولی; ECD; extracellular domain; ICD; intracellular domain; ICN; intracellular fragment of Notch; LNR; LIN12/Notch repeats; LRP; LDL-receptor related protein; mAb; monoclonal antibody; NRR; negative regulatory region; PC; proprotein convertase; PCCD; primitive
A link between two tumorigenic proteins, CD44 and p21WAF1: CD44 increases phorbol ester-induced expression of p21WAF1 by stabilizing its mRNA and extending protein half-life
Keywords: دامنه درون سلولی; p21; CD44; RNA and protein stabilization; Ras/MAPK-pathway; ERM proteins; Agar colony formation; V; empty vector; ctrl; control; ICD; intracellular domain; CHX; cycloheximide; TPA; phorbol-12-myristate 13-acetate; ERM; ezrin, radixin, moesin; MEK; mitogen
Vertebrate extracellular calcium-sensing receptor evolution: Selection in relation to life history and habitat
Keywords: دامنه درون سلولی; CaSR; calcium-sensing receptor; CRD; cysteine-rich domain; ECD; extracellular domain; GABABR; γ-aminobutyric acid type B receptor; GPCR; G protein-coupled receptor; ICD; intracellular domain; LRT; likelihood ratio test; MAP; mitogen-activated protein (ki
Identification and characterization of an alternative splice variant of Mpl with a high affinity for TPO and its activation of ERK1/2 signaling
Keywords: دامنه درون سلولی; Mpl; the thrombopoietin receptor; TPO; thrombopoietin; Mpl-EC; the extracellular domain of thrombopoietin receptor; RT-PCR; reverse transcriptase-polymerase chain reaction; ERK1/2; extracellular signal-regulated protein kinases-1 and -2; T-ERK1/2; Total E
Skeletal tissues in Mozambique tilapia (Oreochromis mossambicus) express the extracellular calcium-sensing receptor
Keywords: دامنه درون سلولی; CaSR; calcium-sensing receptor; EC50; effective concentration producing a 50% response; CRD; cysteine-rich domain; ECD; extracellular domain; GPCR; G protein-coupled receptor; ICD; intracellular domain; IHC; immunohistochemistry; RT-PCR; reverse transcrip
Structural analysis of the intracellular domain of (pro)renin receptor fused to maltose-binding protein
Keywords: دامنه درون سلولی; Ang I; angiotensin I; ATP6ap2; adaptor protein type II vacuolar H+-ATPase; IC; intracellular domain; MBP; maltose binding protein from E. coli; MBP-PRR-IC; MBP fused with the intracellular domain of (pro)renin receptor; PLZF; transcriptional factor prom
Among γ-secretase substrates Notch1 alone is sufficient to block neurogenesis but does not confer self-renewal properties to neural stem cells
Keywords: دامنه درون سلولی; Notch; γ-Secretase; Intracellular domain; Neural stem cell;
Intermediate monomer-dimer equilibrium structure of native ICAM-1: Implication for enhanced cell adhesion
Keywords: دامنه درون سلولی; ICAM-1; intercellular adhesion molecule-1; Ig; immunoglobulin; LFA-1; lymphocyte function-associated antigen-1; GPI; glycosylphophatidylinositol; SDF-1α; stromal-derived factor-1α; FITC; fluorescein isothiocyanate; ICAM-1; Immunoglobulin superfamily; Di
The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis
Keywords: دامنه درون سلولی; APP, amyloid precursor protein; AICD, the intracellular domain of APP; AD, Alzheimer's diseaseAmyloid precursor protein; Intracellular domain; Cell death; Apoptosis; Alzheimer's disease
Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders
Keywords: دامنه درون سلولی; ADAM; a disintegrin and metalloprotease; ACDL; acidic dileucine; ADDL; amyloid-β derived diffusible ligands; APP; amyloid precursor protein; Aph; anterior pharynx defective phenotype; APLP; APP-like protein; AICD; APP intracellular domain; AD; Alzheimer'
Molecular cloning and expression analysis of pig CD81
Keywords: دامنه درون سلولی; CHO; Chinese hamster ovary; Con A; concanavalin A; HCV; hepatitis C virus; ID; intracellular domain; LEL; large extracellular loop; LPS; lipopolysaccharide; PHA; phytohaemagglutinin; RACE; rapid amplification of cDNA ends; SEL; small extracellular loop; T
Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain
Keywords: دامنه درون سلولی; p75 neurotrophin receptor; p75ICD; p75NTR; Intracellular domain; Tumor necrosis factor-α converting enzyme; Photic injury; Apoptosis; Photoreceptor cellsTNFR, Tumor necrosis factor receptor; p75NTR, p75 neurotrophin receptor; p75ECD, p75NTR extracellular
Region-specific growth properties and trophic requirements of brain- and spinal cord-derived rat embryonic neural precursor cells
Keywords: دامنه درون سلولی; brain; differentiation; embryonic; neural progenitor cells; neural stem cells; spinal cord; bFGF or FGF-2; basic fibroblast growth factor; Br; brain; E; embryonic day; EGF; epidermal growth factor; EGF-R; epidermal growth factor receptor; FGFR; basic fibr
Lipoprotein-mediated lipid transport in insects: Analogy to the mammalian lipid carrier system and novel concepts for the functioning of LDL receptor family members
Keywords: دامنه درون سلولی; apoE; apolipoprotein E; apoLp-II/I; apolipophorin II/I; apoLp-I; apolipophorin I; apoLp-II; apolipophorin II; apoLp-III; apolipophorin III; CE; cholesteryl ester; CETP; cholesteryl ester transfer protein; CHO; Chinese hamster ovary; DAG; diacylglycerol; E