کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9886518 | 1537831 | 2005 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lipoprotein-mediated lipid transport in insects: Analogy to the mammalian lipid carrier system and novel concepts for the functioning of LDL receptor family members
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کلمات کلیدی
IDLLDLRApolipophorin IIILPLSR-BIVLDLTRLERCLRP2TMDLLTHDLPapoLp-IIIVitellogenin receptorVgRLRP8LDLpTAGFFATFRLPRTransferrinLBDLRPHDLRAPCETPhigh-density lipoprotein - HDL یا لیپوپروتئین با دانسیته بالا یا چگالی بالاVLDLR - VLDLApoe - آپوapolipoprotein E - آپولیپوپروتئین EFree fatty acid - اسید چرب آزادReceptor-mediated endocytosis - اندوسیتوز مداخله گیرندهCho - برایChinese Hamster Ovary - تخمدان هامستر چینیtriacylglycerol - تری آسیل گلیسرول LTP - تقویت طولانی مدت یا LTP ligand binding domain - دامنه اتصال لیگاندintracellular domain - دامنه درون سلولیtransmembrane domain - دامنه فرابنفشICD - دفیبریلاتورهای کاردیوورتر کاشتنیdiacylglycerol - دیسیل گلیسیرینLipid transfer particle - ذرات انتقال لیپیدDAG - روزLipoprotein lipase - لیپو پروتئین لیپازLipophorin - لیپوفورینvery low density lipoprotein - لیپوپروتئین چگالی بسیار کم استIntermediate density lipoprotein - لیپوپروتئین چگالی متوسطLow-density lipoprotein - لیپوپروتئین کم چگالی یا الدیال LDL - لیپوپروتئین کم چگالی(کلسترول بد)Endocytic Recycling Compartment - محفظه بازیافت آندوسیتیکFamilial hypercholesterolemia - هیپرکلسترولمی فامیلیcholesteryl ester transfer protein - پروتئین انتقال پروتئین کلسترول استreceptor associated protein - پروتئین مرتبط با گیرندهcholesteryl ester - کلسترول استرLDL receptor - گیرنده LDLVLDL receptor - گیرنده VLDLtransferrin receptor - گیرنده انتقالینLipophorin receptor - گیرنده لیپوفورین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In all animals, lipoproteins are used to transport lipids through the aqueous circulation. Lipids are delivered to mammalian cells by two different mechanisms: via endocytic uptake of the complete lipoprotein particle mediated by members of the low density lipoprotein (LDL) receptor (LDLR) family, or by selective delivery of lipoprotein-carried lipids at the cell surface, such as lipid uptake following the action of a lipoprotein lipase. Although many structural elements of the lipid transport system of insects are similar to those of mammals, insect lipoprotein-mediated lipid transport was thought to apply only to the latter concept, since the single lipoprotein acts as a reusable lipid shuttle. However, the recent identification of lipoprotein receptors of the LDLR family in insects suggests that lipid transport in these animals may also adopt the first concept. Yet, the endocytic properties of the insect LDLR homologue appear to deviate from those of the mammalian LDLR family members, resulting in the recycling of endocytosed lipoprotein in a transferrin-like manner. This indicates that a hitherto unknown as well as unexpected function can be added to the plethora of functions of LDLR family members. Analysis of the molecular mechanism of the ligand-recycling function of the insect receptor provides also new insight into the possible functioning of the mammalian family members. In the last several years, mammalian and insect lipoprotein-mediated lipid transport systems have been reviewed separately with respect to functioning and lipid delivery. This review, in which new and important developments in the insect field with respect to our understanding of lipid delivery are discussed with a particular focus on the involvement of the LDLR homologue, aims at comparing the two systems, also from an evolutionary biological perspective, and proposes that the two systems are more similar than assumed previously.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1736, Issue 1, 5 September 2005, Pages 10-29
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1736, Issue 1, 5 September 2005, Pages 10-29
نویسندگان
Kees W. Rodenburg, Dick J. Van der Horst,