The cytoplasmic domain is not involved in directing Class 5 mutant LDL receptors to lysosomal degradation

► Class 5 mutant LDL receptors with bound LDL are rerouted to the lysosomes. ► The cytoplasmic domain is not involved in rerouting Class 5 LDL receptors. ► The mechanism for rerouting LDLR is different from that of signaling receptors.