p73 regulates maintenance of neural stem cell

► TAp73 is expressed in neural stem cells and its expression increases following their differentiation. ► Neural stem cells from p73 null mice have a reduced proliferative potential. ► p73-deficient neural stem cells show reduced expression of members of the Sox-2 and Notch gene families. ► Neurogenic areas are reduced in the brains of embryonic and adult p73−/− mice.