THAP5 is a DNA-binding transcriptional repressor that is regulated in melanoma cells during DNA damage-induced cell death

► THAP5 is a DNA-binding protein and a transcriptional repressor. ► THAP5 is induced in melanoma cells upon exposure to UV or treatment with cisplatin. ► THAP5 induction correlates with the degree of apoptosis in melanoma cell population. ► THAP5 is a pro-apoptotic protein involved in melanoma cell death.