کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10764535 | 1050549 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mitochondria-targeted antioxidant peptide SS31 attenuates high glucose-induced injury on human retinal endothelial cells
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Mitochondria-targeted antioxidant peptide SS31 attenuates high glucose-induced injury on human retinal endothelial cells Mitochondria-targeted antioxidant peptide SS31 attenuates high glucose-induced injury on human retinal endothelial cells](/preview/png/10764535.png)
چکیده انگلیسی
⺠ROS and mitochondrial dysfunction have been described as the central part of the pathogenesis of diabetic retinopathy. ⺠SS31 is a novel class of mitochondria-targeted antioxidant peptide, and it can scavenge H2O2 and ONOO- and inhibit lipid peroxidation. ⺠In our study, we provided the first evidence that SS31 could attenuate the high glucose-induced injuries on HRECs by reducing ROS production, stabilize mitochondrial potential and decrease the release of cytochrome c from mitochondria to cytoplasm. ⺠In addition, SS31 also could decrease the expression of caspase-3 and increase the expression of Trx-2. ⺠Our study suggests that SS31 has excellent potential as a new therapeutic for the treatment of diabetic retinopathy and other oxidative stress related diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 404, Issue 1, 7 January 2011, Pages 349-356
Journal: Biochemical and Biophysical Research Communications - Volume 404, Issue 1, 7 January 2011, Pages 349-356
نویسندگان
Jianqiao Li, Xiaoyun Chen, Wei Xiao, Wei Ma, Tao Li, Juan Huang, Xialin Liu, Xiaoling Liang, Shibo Tang, Yan Luo,