کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10765054 | 1050581 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of tetraphenylethylene-based fluorescent oligosaccharide probes for detection of influenza virus
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Tetraphenylethylene (TPE) derivatives have strong fluorescence in aggregated state. We designed and synthesized a tetraphenylethylene derivative bearing alkyne groups which were used for combination by click chemistry. The new TPE compound bearing alkyne groups was used to synthesize fluorescence oligosaccharide probes which have lactosyl and 6â²-sialyllactosyl moieties as ligands. We found that the TPE compounds bearing lactosyl and 6â²-sialyllactosyl moieties were useful for detection of RCA120 and SSA lectins, respectively. Moreover, we have shown that TPE-based fluorescent oligosaccharide probe bearing 6â²-sialyllactose moiety can be utilized as a “turn-on” fluorescent sensor for detection of influenza virus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 394, Issue 1, 26 March 2010, Pages 200-204
Journal: Biochemical and Biophysical Research Communications - Volume 394, Issue 1, 26 March 2010, Pages 200-204
نویسندگان
Tomohisa Kato, Atsushi Kawaguchi, Kyosuke Nagata, Kenichi Hatanaka,