کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10766660 | 1050667 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diameter of tumor blood vessels is a good parameter to estimate HIF-1-active regions in solid tumors
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کلمات کلیدی
LUCGFPHIF-1HREHypoxia-inducible factor-1 (HIF-1)oxygen-dependent degradationAngiogenesis - آنژیوژنزOptical imaging - تصویربرداری نوریHypoxia-response element - عنصر پاسخ هیپوکسیhypoxia-inducible factor-1 - فاکتور القای هیپوکسی -1ODD - فردluciferase - لوسیفرازTumor microenvironment - میکرو محیط زیست تومورHypoxia - هیپوکسیgreen fluorescent protein - پروتئین فلورسنت سبز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
As the transcriptional activity of hypoxia-inducible factor 1 (HIF-1) is associated with resistance of tumor cells to current antitumor therapies, the spatiotemporal dynamics of HIF-1-active regions has been of great interest as a therapeutic target. In the present study, we established a unique cancer cell line, which changes color HIF-1-dependently, and monitored it during tumor progression. In imaging experiments, HIF-1-active cells appeared over the tumor xenograft, but dramatically decreased in number as blood vessels developed around the tumor. The remaining HIF-1-active cells at the center of the xenograft also disappeared after neovascularization. Thereafter, tumor growth was accelerated and HIF-1-active cells reappeared in different regions. The distance between HIF-1-active cells and the nearest vessels correlated to the diameter of the vessel (r = 0.801). These results provide a basic knowledge of how to estimate the spatiotemporal dynamics of HIF-1-active cells using information about the image-guided architecture of tumor blood vessels.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 373, Issue 4, 5 September 2008, Pages 533-538
Journal: Biochemical and Biophysical Research Communications - Volume 373, Issue 4, 5 September 2008, Pages 533-538
نویسندگان
Hiroshi Harada, Xuejun Xie, Satoshi Itasaka, Lihua Zeng, Yuxi Zhu, Akiyo Morinibu, Kazumi Shinomiya, Masahiro Hiraoka,