کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10767053 | 1050696 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gene expression profiles in peripheral blood mononuclear cells reflect the pathophysiology of type 2 diabetes
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کلمات کلیدی
c-Jun N-terminal kinase - C-Jun N-terminal kinaseGene expression - بیان ژنDiabetes - بیماری قندDNA chip - تراشه دیجیتالOxidative stress - تنش اکسیداتیوPeripheral blood mononuclear cell - سلول تک هسته ای خون محیطیOxidative phosphorylation - فسفوریلاسیون اکسیداتیوMitochondria - میتوکندریاGlycemic control - کنترل قند خون
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We hypothesized that systemically circulating peripheral blood mononuclear cells (PBMCs) reflect the pathophysiology of type 2 diabetes. PBMCs were obtained from 18 patients with type 2 diabetes and 16 non-diabetic subjects. The expression of genes in the PBMCs was analyzed by using a DNA chip followed by statistical analysis for specific gene sets for biological categories. The only gene set coordinately up-regulated by the existence of diabetes and down-regulated by glycemic control consisted of 48 genes involved in the c-Jun N-terminal kinase (JNK) pathway. In contrast, the only gene set coordinately down-regulated by the existence of diabetes, but not altered by glycemic control consisted of 92 genes involved in the mitochondrial oxidative phosphorylation (OXPHOS) pathway. Our findings suggest that genes involved in the JNK and OXPHOS pathways of PBMCs may be surrogate transcriptional markers for hyperglycemia-induced oxidative stress and morbidity of type 2 diabetes, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 361, Issue 2, 21 September 2007, Pages 379-384
Journal: Biochemical and Biophysical Research Communications - Volume 361, Issue 2, 21 September 2007, Pages 379-384
نویسندگان
Toshinari Takamura, Masao Honda, Yoshio Sakai, Hitoshi Ando, Akiko Shimizu, Tsuguhito Ota, Masaru Sakurai, Hirofumi Misu, Seiichiro Kurita, Naoto Matsuzawa-Nagata, Masahiro Uchikata, Seiji Nakamura, Ryo Matoba, Motohiko Tanino, Ken-ichi Matsubara,