کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10767350 1050723 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Regulation of human umbilical cord blood-derived multi-potent stem cells by autogenic osteoclast-based niche-like structure
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Regulation of human umbilical cord blood-derived multi-potent stem cells by autogenic osteoclast-based niche-like structure
چکیده انگلیسی
Stem cell niches provide the micro-environment for the development of stem cells. Under our culturing regimen, a kind of osteoclast-centralized structure supports the proliferation of MSCs, derived from human cord blood, once they reside on osteoclasts. MSCs in this structure expressed Oct4 which is a marker of embryonic stem cells. Floating daughter cells of MSCs colony showed abilities to differentiate into osteocyte, adipocyte, and neuronal progenitor cells. Compared with the easy senescence of MSCs without this niche-like structure in vitro, these results suggested that osteoclasts might play an important role the development and maintenance of Umbilical cord blood (UCB)-derived MSCs and might provide a means to expand UCB-MSCs in vitro, more easily, through a stem cell niche-like structure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 357, Issue 1, 25 May 2007, Pages 92-98
نویسندگان
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