کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10767999 | 1050802 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Electro-transfer of small interfering RNA ameliorated arthritis in rats
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Electro-transfer of small interfering RNA ameliorated arthritis in rats Electro-transfer of small interfering RNA ameliorated arthritis in rats](/preview/png/10767999.png)
چکیده انگلیسی
RNA interference provides the powerful means of sequence-specific gene silencing. Particularly, small interfering RNA (siRNA) duplexes may be potentially useful for therapeutic molecular targeting of human diseases, although novel delivery systems should be devised to achieve efficient and organ-specific transduction of siRNA. In the present study, we demonstrated that electro-transfer of a siRNA-polyamine complex made efficient and specific gene knockdown possible in the articular synovium. Targeted suppression of the tumor necrosis factor-α gene through this procedure significantly ameliorated collagen-induced arthritis in rats. Our results suggest the potential feasibility of therapeutic intervention with RNA medicines for treatment of rheumatoid and other locomotor diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 336, Issue 3, 28 October 2005, Pages 903-908
Journal: Biochemical and Biophysical Research Communications - Volume 336, Issue 3, 28 October 2005, Pages 903-908
نویسندگان
Atsuo Inoue, Kenji A. Takahashi, Osam Mazda, Ryu Terauchi, Yuji Arai, Tsunao Kishida, Masaharu Shin-Ya, Hidetsugu Asada, Toru Morihara, Hitoshi Tonomura, Suzuyo Ohashi, Yoshiteru Kajikawa, Yutaka Kawahito, Jiro Imanishi, Mitsuhiro Kawata, Toshikazu Kubo,