کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10770349 1050833 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Promoted electron transfer of mitoxantrone binding with DNA by cytochrome c
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Promoted electron transfer of mitoxantrone binding with DNA by cytochrome c
چکیده انگلیسی
A promoted electron transfer of an antitumor drug, mitoxantrone (MTX), intercalating into DNA duplex was successfully obtained upon addition of cytochromes c (cyt. c) in NaAc-HAc buffer solution (pH 4.5). The experimental results suggested that co-existence of MTX and cyt. c in the DNA helix is an important factor for accelerated electron transfer of MTX, where the promoter, cyt. c, operated smoothly through the DNA bridge. The UV/Vis spectroscopic experiments further confirmed the interaction process. Furthermore, a possible mechanism of such reaction was also discussed in this paper.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 331, Issue 4, 17 June 2005, Pages 947-952
نویسندگان
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