کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10771980 1050846 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
SMHS1 is involved in oxidative/glycolytic-energy metabolism balance of muscle fibers
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
SMHS1 is involved in oxidative/glycolytic-energy metabolism balance of muscle fibers
چکیده انگلیسی
With the aim of finding important mediators of muscle atrophy, we cloned SMHS1, a novel gene that was found to be upregulated in rat soleus muscle atrophied by restriction of activity. The SMHS1 amino acid sequence shares 65% similarity with RTP801-which is a cellular stress response protein regulated by HIF-1-but SMHS1 expression was demonstrated to be independent of HIF-1. SMHS1 was found to be mainly expressed in skeletal muscle, and comparisons of its expression in atrophied versus hypertrophied muscles and in oxidative versus glycolytic muscles suggested that SMHS1 contributes to the muscle energy metabolism phenotypes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 326, Issue 4, 28 January 2005, Pages 788-793
نویسندگان
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