کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10797838 | 1053228 | 2011 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oxidation-driven protein import into mitochondria: Insights and blind spots
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کلمات کلیدی
ToMcopper chaperone for SOD1Erv1CCS1TIMITSSOD1MTSGSHIMSMISS - از دست دادنtranslocase of the outer membrane - انتقال غشای خارجیtranslocase of the inner membrane - انتقال غشای داخلیProtein oxidation - اکسیداسیون پروتئینProtein folding - تاشدگی پروتئینsuperoxide dismutase 1 - سوپر اکسید دیسموتاز 1intermembrane space - فضای بین محوریMia40 - میا 40Mitochondria - میتوکندریاreduced glutathione - کاهش گلوتاتیونGlutathione - گلوتاتیون
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
The intermembrane space of mitochondria contains a dedicated machinery for the introduction of disulfide bonds into proteins. In this case, oxidative protein folding is believed to drive the vectorial translocation of polypeptides after their synthesis in the cytosol across the mitochondrial outer membrane. Substrates of this system are recognized by a hydrophobic binding cleft of the oxidoreductase Mia40 which converts them into an oxidized stably folded conformation. Mia40 is maintained in an oxidized, active conformation by the sulfhydryl oxidase Erv1, a homodimeric flavoenzyme, which can form disulfide bonds de novo. Erv1 passes electrons on to cytochrome c and further to the respiratory chain. The components of this system, their structures and the mechanisms of disulfide bond formation were analyzed only very recently. This review discusses our knowledge about this system as well as open questions which still wait to be addressed. This article is part of a Special Issue entitled Protein translocation across or insertion into membranes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1808, Issue 3, March 2011, Pages 981-989
Journal: Biochimica et Biophysica Acta (BBA) - Biomembranes - Volume 1808, Issue 3, March 2011, Pages 981-989
نویسندگان
Jan Riemer, Manuel Fischer, Johannes M. Herrmann,