Curcumin's pre-incubation temperature affects its inhibitory potency toward amyloid fibrillation and fibril-induced cytotoxicity of lysozyme

► Fibrillogenesis of hen lysozyme is attenuated by thermally pre-treated curcumin. ► Thermally pre-treated curcumin enhances lysozyme's structural stability. ► Thermally pre-treated curcumin protects cells against fibril-induced cell death. ► Curcumin's protection toward fibril cytotoxicity relates to its thermostability.