A method to assess the migration properties of cell-derived microparticles within a living tissue

► A method is given to examine, in vivo, the fate of cell-derived microparticles (MP) ► The MP can be visualized upon injection into developing zebrafish embryos. ► The fate of MP in the intercellular space relies on particle's phenotype. ► Calcium-induced MP diffuse within the living cells, but not apoptosis-derived MP.