The dynamin GTPase OPA1: More than mitochondria?

► OPA1 is the best characterized mitochondrial fusion protein. ► Its structure and function are evolutionarily conserved. ► A complex proteolytic cascade governs its role in mitochondria dynamics, apoptosis, and quality control. ► The recently proposed localization of OPA1 on the lipid droplets, and function as an AKAP, remains controversial.