The IP3 receptor-mitochondria connection in apoptosis and autophagy

► The Ca2+ in the mitochondria is crucial for cell fate. ► The localization of the IP3 receptors determines the Ca2+ uptake in the mitochondria. ► IP3 receptor function and localization is regulated by protein-protein interactions. ► IP3 receptors interact with mitochondrial Ca2+ uptake sites. ► The strength of the interactions affect the occurrence of apoptosis or autophagy.