کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10803175 | 1055801 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Signaling via NF-κB in the nervous system
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Nuclear factor kappa B (NF-κB) is an inducible transcription factor present in neurons and glia. Recent genetic models identified a role for NF-κB in neuroprotection against various neurotoxins. Furthermore, genetic evidence for a role in learning and memory is now emerging. This review highlights our current understanding of neuronal NF-κB in response to synaptic transmission and summarizes potential physiological functions of NF-κB in the nervous system. This article contains a listing of NF-κB activators and inhibitors in the nervous system, furthermore specific target genes are discussed. Synaptic NF-κB activated by glutamate and Ca2+ will be presented in the context of retrograde signaling. A controversial role of NF-κB in neurodegenerative diseases will be discussed. A model is proposed explaining this paradox as deregulated physiological NF-κB activity, where novel results are integrated, showing that p65 could be turned from an activator to a repressor of anti-apoptotic genes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1745, Issue 3, 30 September 2005, Pages 287-299
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research - Volume 1745, Issue 3, 30 September 2005, Pages 287-299
نویسندگان
Barbara Kaltschmidt, Darius Widera, Christian Kaltschmidt,