Regulation of β-catenin stabilization in human platelets

► Sustained aggregation of platelets in the presence of calcium degraded β-catenin. ► β-catenin degradation was not observed in absence of aggregation. ► Proteolysis was blocked partially by inhibitors of both calpain and proteasome. ► Inhibition of PKC precluded β-catenin degradation, suggestive of role of PKC.