(+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans

► (+)-Medioresinol triggered accumulation intracelluar ROS in Candida albicnas cells. ► (+)-Medioresinol may induced mitochondrial membrane depolarzation and then Cyt c release from mitochondria to cytosol. ► (+)-Medioresinol activates metacaspases. ► (+)-Medioresinol induced apoptosis mediated mitochondria.