Keywords: Bull; Sperm; Mitochondrial membrane potential; JC-1; Cryopreservation; Glycerol;
مقالات ISI (ترجمه نشده)
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Keywords: ad-virDRP1K38A; dominant-negative DRP1; AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide; ATP5; ATP synthase subunit 5; DAG; diacylglycerol; DRP1; dynamin related protein 1; ER; endoplasmic reticulum; FAO; fatty acid beta-oxidation; JC-1; 5,5â²,6,6â
Keywords: Apaf-1; Apoptotic protease-activating factor-1; A498; Renal proximal tubular carcinoma; BCA; Bicinchoninic acid; Bax; Bcl-2 associated X protein; Bcl-2; B-cell lymphoma 2; BSA; Bovine Serum Albumin; Cdc25; Cell-division control protein 25(Dual-Specificity
Keywords: Apoptosis; Benzophenone; Cytotoxicity; Multi-drug resistance; Ferroptosis; Phytochemicals; ABC; ATP-binding cassette; BCRP; breast cancer resistance protein; DMSO; dimethylsulfoxide; EGFR; epidermal growth factor receptor; FITC; flourescein isothiocynate;
Keywords: SSCs; Spermatogonial stem cells; H3K9me3; Histone H3 lysine 9 trimethylation; H3K27me3; Histone H3 lysine 27 trimethylation; ESET; ERG-associated protein with SET domain; KDM3A; Lysine (K)-specific demethylase 3A; ROS; reactive oxygen species; DSB; DNA do
Keywords: ABC; adenosine triphosphate-binding cassette; ACP; Ananas comosus peels; AHT; Arachis hypogaea twigs; IARC; According to the International Agency for Research on Cancer; ArHL; Artocarpus heterophyllus leaves; BCRP; breast cancer resistance protein; CLR; C
Keywords: DCA; Dichloroacetate; ECAR; extra cellular acidification rate; JC-1; 5,5â²,6,6â²-tetrachloro-1,1â²,3,3â²-tetraethylbenzimidazolycarbocyanine; MMP; ÎÏm, mitochondrial membrane potential; NAD+; Â nicotinamide adenine dinucleotide; NADH; reduced nicoti
Keywords: Cardiotoxicity; Cancer chemotherapy; Cardiac function; Terminalia; Echocardiography; Cardioprotection; CO; cardiac output; DHE; dihydroethidin; DOX; doxorubicin; EF; ejection fraction; FS; fractional shortening; JC-1; 5,5â²,6,6â²-tetrachloro-1,1â²,3,3â
Keywords: Mouse Model; Lipid Metabolism; 1-Carbon Metabolism; Prognostic; ALT; alanine aminotransferase; DG; diglycerides; DMR; differentially methylated DNA regions; FA; fatty acids; GSH; glutathione; JC-1; 5,5,6,6-tetrachloro-1,1,3,3-tetraethylbenzimidazolyl-carb
Keywords: CM; conditioned medium; OCCs; ovarian cancer cells; CPD; cumulative number of population doublings; Cx43; connexin 43; H2O2; hydrogen peroxide; HGF; hepatocyte growth factor; HPMCs; human peritoneal mesothelial cells; JC-1; 5,5',6,6'-tetrachloro-1,1',3,3'
Keywords: Akt; Protein kinase B; CHD; Coronary heart disease; Cx; Connexin; Drp-1; Dynamin related protein 1; EF; Ejection fraction; GAPDH; Glyceraldehyde 3-phosphate dehydrogenase; HSP60; Heat shock protein 60; JC-1; Tetraethylbenzimidazolylcarbocyanine iodide; LV
Keywords: AGEs; advanced glycation end products; LA; alpha lipoic acid; BAEC; bovine aortic endothelial cells; BCA; bicinchoninic acid; BH4; tetrahydrobiopterin; CaI; calcium ionophore; CAT; catalase (EC 1.11.1.6); CMD; cardiometabolic disease; CVD; cardiovascular
Keywords: 5-FU; 5-fluorouracil; CRC; curcumin; TCS; thiolated chitosan; FT-IR; Fourier transform infrared spectroscopy; DDA; degree of deacetylation; DLS; dynamic light scattering; PBS; phosphate buffered saline; SEM; scanning electron microscope; FBS; fetal bovine
Keywords: ATIC; allylisothiocyanate; GLUT4; glucose transporter 4; mtDNA; mitochondrial DNA; FFA; free fatty acid; OCR; Oxygen consumption rate; DMEM; Dulbecco's Modified Eagle's medium; FBS; fetal bovine serum; 2-NBDG; 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amin
Keywords: AA; antimycin A; BSA; bovine serum albumin; tBH; tert-butyl hydroperoxide; DAPI; 4,6-diamidino-2-phenylindole dihydrochloride; DIC; dicarboxylate carrier; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GSH; glutathione; JC-1; 5,5â²,6,6â²-tetrachloro-1
Prolonged treatment with mevalonolactone induces oxidative stress response with reactive oxygen species production, mitochondrial depolarization and inflammation in human glioblastoma U-87 MG cells
Keywords: Mevalonate kinase deficiency; Mevalonolactone; Human glioblastoma U-87â¯MG cells; Oxidative stress; Mitochondrial damage; Inflammation; ACTB; actin β gene; H2DCFDA; 2â²,7â²-dichlorofluorescein diacetate; HemeOX; heme oxygenase gene; HIDS; Hyper IgD Sy
Apoptosis and pro-death autophagy induced by a spirostanol saponin isolated from Rohdea chinensis (Baker) N. Tanaka (synonym Tupistra chinensis Baker) on HL-60 cells
Keywords: Spirostanol saponin; Autophagy; Apoptosis; Rohdea chinensis; Human acute promyelocytic leukemia; Akt; protein kinase B; AMPK; adenosine 5â²-monophosphate-activated protein kinase; Baf-A1; bafilomycin A1; FBS; fetal bovine serum; JC-1; 5,5´,6,6´-tetrach
γ-Mangostin, a xanthone from mangosteen, attenuates oxidative injury in liver via NRF2 and SIRT1 induction
Keywords: ALT; alanine aminotransferase; ARE; antioxidant responsive element; AST; aspartate transaminase; ATRA; all--retinoid acid; CCl4; carbon tetrachloride; DCFH-DA; 2â²,7â²-dichlorofluorescin diacetate; γ-man; γ-mangostin; GSH; glutathione; HO-1; heme oxyg
The evaluation of potent antitumor activities of shikonin coumarin-carboxylic acid, PMMB232 through HIF-1α-mediated apoptosis
Keywords: HIF-1α; hypoxia-inducible factor alpha 1; DMAP; 4 dimethyamino- pyridine; DCC; N, N' dicyclohexylcarbodiimide; DMEM; Dulbecco's modified Eagle's medium; MTT; 3-(4 5-dimethyl-2-thiazolyl)-2 5-diphenyl-2-H-tetrazolium bromide; IC50; Half of maximal i
A Morpholino Oligomer Therapy Regime That Restores Mitochondrial Function and Prevents mdx Cardiomyopathy
Keywords: cardiomyopathy; L-type calcium channels; mitochondria; DMD; Duchenne muscular dystrophy; ICa-L; L-type Ca2+ channel; JC-1; 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine iodide; mdx; murine model of Duchenne muscular dystrophy; PMO;
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1
Keywords: PDK; pyruvate dehydrogenase kinase; PDC; pyruvate dehydrogenase complex; MMP; mitochondrial membrane potential; ROS; reactive oxygen species; OXPHOS; oxidative phosphorylation; TCA; tricarboxylic acid; PDPs; pyruvate dehydrogenase phosphatases; DCA; dichl
Tannic acid attenuated irradiation-induced apoptosis in megakaryocytes
Keywords: TA; Tannic acid; IR; Ionizing radiation; ROS; reactive oxygen species; Nox1; NAPDH oxidase 1; JC-1; 5,5â²,6,6â²-tetraethylbenzimidazolylcar-bocyanine iodide; TBI; total body irradiation; MMP; Mitochondrial membrane potential; Tannic acid; Irradiation; A
Morusin induces paraptosis-like cell death through mitochondrial calcium overload and dysfunction in epithelial ovarian cancer
Keywords: Morusin; Paraptosis-like cell death; EOC; VDAC; Mitochondrial Ca2+ overload; Mitochondrial dysfunction; EOC; epithelial ovarian cancer; VDAC; voltage-dependent anion channel; DIDS; 4, 4â²-diisothiocyanostilbene-2, 2â²-disulfonic acid; NAC; N-acetyl-l-cy
In vitro toxicity evaluation of estragole-containing preparations derived from Foeniculum vulgare Mill. (fennel) on HepG2 cells
Keywords: Botanical mixtures; Estragole; Foeniculum vulgare; Genotoxicity; HepG2; Toxicity; NQO; 4-nitroquinoline N-oxide; AO; acridine orange; CBMN assay; cytokinesis-block micronucleus assay; DAPI; 4â²-6-diamidino-2-phenylindole; EtOH; ethanol; FSEO; fennel seed
A pivotal role for NF-κB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid
Keywords: Macrophage; Atherosclerosis; Myeloperoxidase; Oxidative stress; Inflammation; Cytokine; BSA; bovine serum albumin; CCCP; carbonyl cyanide m-chlorophenyl hydrazone; HOCl; hypochlorous acid; HOSCN; hypothiocyanous acid; HUVEC; human umbilical vein endotheli
A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer
Keywords: 7-AAD; 7-amino-actinomycin D; ABC; ATP-binding cassette; AEC; 3-amino-9-ethyl carbazole; ATD; acute toxicity determination; Atg5; autophagy protein 5; ATP; adenosine-5â²-triphosphate; BCL-2; B-cell lymphoma 2; Bip/GRP78; binding immunoglobulin protein/78
A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death
Keywords: Ardisiacrispin B; Cell cycle distribution; Cytotoxicity; Ferroptosis; Mitochondrial membrane potential; Saponin; ABC; ATP-binding cassette; BCRP; breast cancer resistance protein; DCF; dichlorofluoresceine; DMSO; dimethylsulfoxide; EGFR; epidermal growth
3â²-Hydroxy-3,4â²-dimethoxyflavone-induced cell death in human leukaemia cells is dependent on caspases and reactive oxygen species and attenuated by the inhibition of JNK/SAPK
Keywords: Apoptosis; Caspases; Cell cycle; Cytotoxicity; Flavonoids; ERKs; extracellular signal-regulated kinases; IC50; 50% inhibition of cell growth; JC-1; 5,5â²,6,6â²-tetrachloro-1,1â²,3,3â²-tetraethylbenzimidazolylcarbocyanine iodide; JNK; c-Jun N-terminal
Cannabidiol induced apoptosis in human monocytes through mitochondrial permeability transition pore-mediated ROS production
Keywords: AKT; Protein kinase B; Bcl-2; B-cell lymphoma 2; calcein-AM; calcein-acetoxymethylester; CBD; cannabidiol; CM-H2DCF-DA; 5,6-chloromethyl-2,7-dichlorodihydrofluorescin diacetate; COX IV; cytochrome c oxidase subunit IV; CsA; cyclosporin A; Cyt c; cytochrom
Synergistic interaction of β-caryophyllene with aromadendrene oxide 2 and phytol induces apoptosis on skin epidermoid cancer cells
Keywords: P. missionis; β-caryophyllene; Aromadendrene oxide 2; Phytol; Synergy; Apoptosis; Cancer therapy; EO; essential oil; β-C; β-caryophyllene; AO-(2); aromadendrene oxide 2; P; phytol; β-caryophyllene/aromadendrene oxide 2; (β-C/AO-(2); β-caryophyllene/
Distinct apoptotic blocks mediate resistance to panHER inhibitors in HER2+ breast cancer cells
Keywords: ÎÏm; mitochondrial membrane potential; FCCP; carbonylcyanide-4-(trifluoromethoxy)-phenylhydrazone; FITC; fluorescein isothiocyanate; BSA; bovine serum albumin; JC-1; 5,5â²,6,6â²-tetrachloro-1,1â²,3,3â²-tetraethylbenzimidazolylcarbocyanine iodide; MO
Depletion of oxaloacetate decarboxylase FAHD1 inhibits mitochondrial electron transport and induces cellular senescence in human endothelial cells
Keywords: BrdU; 5-bromo-2â²deoxy-uridine; ETC; electron transport chain; FAHD1; fumarylacetoacetate hydrolase (FAH) domain-containing protein 1; FCCP; carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone; HUVEC; human umbilical vein endothelial cells; JC-1; 5.5â
The effect of resveratrol, its naturally occurring derivatives and tannic acid on the induction of cell cycle arrest and apoptosis in rat C6 and human T98G glioma cell lines
Keywords: DMEM; Dulbecco's Modified Eagle's Medium; DMSO; dimethylsulfoxide; FBS; fetal bovine serum; JC-1; 5,5â²,6,6â²-tetrachloro-1,1â²,3,3â²-tetraethylbenzimidazolo-carbocyanine iodide; MTP; mitochondrial transmembrane potential; MTT; 3-(4,5-dimethylthiazol-
Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells
Keywords: SIRT1; Sirtunin; AURKB; Aurora B kinase; CRC; Colorectal cancer; BMFC; Butea monosperma flower compounds; mRNA; Messenger ribonucleic acid GSK Glycogen synthase kinase; WHO; World health organization; HDAC; Histone deacetylase; CSCs; Cancer stem cells; Bm
Anti-colon cancer activity of Murraya koenigii leaves is due to constituent murrayazoline and O-methylmurrayamine A induced mTOR/AKT downregulation and mitochondrial apoptosis
Keywords: DCFH-DA; 2,7-dichlorodihydrofluorescein diacetate; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; JC-1; 5,5â²,6,6â²-tetrachloro-1,1â²,3,3â²-tetraethylbenzimidazolylcarbocyanine iodide; MMP; mitochondrial membrane potential; MTT
Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity
Keywords: AITC; allyl isothiocyanate; ALT; alanine transaminase; An V; annexin V; ANOVA; analysis of variances; APC; allophycocyanin; AST; aspartate transaminase; b.w.; body weight; BITC; benzyl isothiocyanate; BTMS; bromotrimethylsilane; BuITC; butyl isothiocyanat
MiR-126 reverses drug resistance to TRAIL through inhibiting the expression of c-FLIP in cervical cancer
Keywords: TRAIL; TNF-related apoptosis-inducing ligand; Hela-TR; TRAIL-resistant Hela; SiHa-TR; TRAIL-resistant SiHa; C-FLIP; CASP8 and FADD like apoptosis regulator; TNF-α; tumor necrosis factor-α; FasL; Fas ligand; MiR-126; microRNA-126; 3â² UTR; 3â²-untransl
Cytosolic calcium mediates RIP1/RIP3 complex-dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells
Keywords: AO; acridine orange; ATP; adenosine triphosphate; CaMK; calcium-calmodulin kinase; EGTA; ethylenebis(oxyethylenenitrilo)tetraacetic acid; IM-54; 2-(1H-Indol-3-yl)-3-pentylamino-maleimide; JC-1; 5,5â²,6,6â²-tetrachloro-1,1â²,3,3â²-tetraethylbenzimidazo
Azidothymidine-triphosphate impairs mitochondrial dynamics by disrupting the quality control system
Keywords: ATP; adenosine triphosphate; AZT; 3ê-azido-3ê-deoxythymidine; AZT-DP; AZT diphosphate; AZT-MP; AZT monophosphate; AZT-TP; AZT-triphosphate; calcein-AM; calcein acetoxymethyl ester; cDNA; complementary DNA; DHE; dihydroethidium; DMEM; Dulbecco's Modifi
Mitochondrial permeability and toxicity of diethylhexyl and monoethylhexyl phthalates on TK6 human lymphoblasts cells
Keywords: DEHP; diethylhexyl phthalate; MEHP; monoethylhexyl phthalate; DMSO; dimethyl sulfoxide; JC-1; 5,5â²,6,6â²-tetrachloro-1,1â²,3,3â²-tetraethylbenzimidazolocarbocyanine iodide; ROS; reactive oxygen species; FSU; fluorescence standard units; IC50; inhibit
Impact of simultaneous stimulation of 5-lipoxygenase and myeloperoxidase in human neutrophils
Keywords: MVP; 1-methyl-2-vinylpyridinium triflate; 4-ABAH; 4-aminobenzoic acid hydrazide; APF; aminophenyl fluorescein; JC-1; J-aggregate forming cationic dye; Leukotriene; HOCl; Inflammation; Glutathione; Hydrogen peroxide;
Isoquercitrin, isolated from Aster yomena triggers ROS-mediated apoptosis in Candida albicans
Keywords: MeOH; methanol; EtOAc; ethyl acetate; CFU; colony-forming unit; ROS; reactive oxygen species; NAC; N-acetylcysteine; H2DCFDA; 2',7'-dichlorodihydrofluorescein diacetate; TUNEL; terminal deoxynucleotidyl transferase dUTP nick end labeling; DAPI; 4',6-diami
Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer
Keywords: 4E-BP-1; eukaryotic initiation factor 4E binding protein-1; ATF4; activating transcription factor 4; Bcl2; B-cell lymphoma 2; C/EBP; CAAT/enhancer binding protein; cdc-2; cyclin-dependent kinase 1 (cell division cycle protein 2); CHOP; CAAT/enhancer bindi
Oxidative stress plays major role in mediating apoptosis in filarial nematode Setaria cervi in the presence of trans-stilbene derivatives
Keywords: Apaf; apoptotic protease activating factor; BCl-2; B-cell lymphoma 2; CED; cell-death abnormal; CM; culture media; DEC; diethyl-carbamazine citrate; DMSO; dimethyl sulfoxide; EGL; egg laying defective; EtBr; ethidium bromide; FBS; fetal bovine serum; GAPD
2-Methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone, induces NO-dependent apoptosis and necroptosis by H2O2-dependent JNK activation in cancer cells
Keywords: CAT; catalase; DAF-FM; 4-amino-5-methylamino-2â²,7â²-mifluorofluorescein; DCFH2-DA; 2â²,7â²-dichlorodihydrofluorescein diacetate; DHE; dihydroethidium; DMSO; dimethyl sulfoxide; DPI; diphenyleneiodonium; ERK; extracellular signal regulated kinase; FLR
Cellular determinants involving mitochondrial dysfunction, oxidative stress and apoptosis correlate with the synergic cytotoxicity of epigallocatechin-3-gallate and menadione in human leukemia Jurkat T cells
Keywords: Epigallocatechin-3-gallate (PubChem CID: 65064); Menadione sodium bisulfite (PubChem CID: 23665888); Cyclosporin A (PubChem CID: 5284373); Antimycin A (PubChem CID: 14957); Rotenone (PubChem CID: 6758); 7-AAD; 7-Aminoactinomycin D; AM; antimycin A; CM-H2D
Matrine suppresses proliferation and induces apoptosis in human cholangiocarcinoma cells through suppression of JAK2/STAT3 signaling
Keywords: Ac-DEVD-CHO; N-acetyl-Asp-Glu-Val-Asp-aldehyde; EGCG; epigallocatechin-3-gallate; IL-6; interleukin-6; JAK; Janus kinase; JC-1; 5,5â²,6,6â²-tetrachloro-1,1â²,3,3â²-tetraethylbenzimi-dazolylcarbocyanine iodide; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-dip
Effect of cigarette smoke on DNA damage, oxidative stress, and morphological alterations in mouse testis and spermatozoa
Keywords: CS; cigarette smoke; FTC; Federal Trade Commission; TPM; total particulate matter; TBARS; thiobarbituric acid reactive substances; MDA; malondialdehyde; ROS; reactive oxygen species; DCFH-DA; 2â²,7â²-dichlorofluorescein diacetate; DCF; dichlorofluoresce
Mitochondrial iron accumulation exacerbates hepatic toxicity caused by hepatitis C virus core protein
Keywords: HCV; hepatitis C virus; HCC; hepatocellular carcinoma; ROS; reactive oxygen species; Fe-NTA; ferric nitrilacetic acid; JC-1; 5,5â²,6,6â²-tetrachrolo-1,1â²,3,3â²-tetraethylbenzimidazoly-carbocyanine iodide; CCCP; carbonyl cyanide-m-chlorophenyl hydrazi
Mechanistic study of programmed cell death of root border cells of cucumber (Cucumber sativus L.) induced by copper
Keywords: Root border cells (RBCs); Copper (Cu); Programmed cell death (PCD); Cucumber (Cucumber sativus L.); Cu; copper; RBCs; root border cells; PCD; programmed cell death; MTP; mitochondrial trans-membrane potential; ÎΨm; mitochondrial membrane potential; JC-1