Pathophysiologic role of hepatocyte nuclear factor 6

► Hepatocyte nuclear factor 6 (HNF6) is one of liver-enriched transcription factors. ► HNF6 regulates an intricate network and mediates complex biological processes. ► HNF6 is correlated to cell proliferation, differentiation and organgenesis, hepatic metabolism. ► Future study on HNF6 may involve apoptosis, oncogenesis, and modulation of inflammatory response. ► HNF6 pathway represents attractive therapeutic target for the treatment of relative diseases.