کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10835134 | 1066022 | 2012 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nitric oxide at the CVLM is involved in the attenuation of the reflex bradycardia in renovascular hypertensive rats
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کلمات کلیدی
NTSSNS2K1CPulse intervalCVLMVLMNOSRVLMROS - ROSrostral ventrolateral medulla - آرام آرامl-arginine - آرژینین الsuperoxide anion - آنیون سوپر اکسیدl-Arg - ال-آرژینینCNS - دستگاه عصبی مرکزیsympathetic nervous system - سیستم عصبی سمپاتیکcentral nervous system - سیستم عصبی مرکزیParasympathetic nervous system - سیستم عصبی پاراسمپاتیکSham - شامShr - شریHeart rate - ضربان قلبmean arterial pressure - فشار متوسط شریانیBlood pressure - فشارخونPVN - مالیات بر ارزش افزودهventrolateral medulla - مدول ونتیلاتورcaudal ventrolateral medulla - مدولال ventrolateral کادالnormotensive rats - موش صحراییspontaneous hypertensive rats - موش های پرپرتروفیک خودبهخودیmillisecond - میلی ثانیهmap - نقشهNitric oxide - نیتریک اکسیدnitric oxide synthase - نیتریک اکسید سنتازnucleus of the solitary tract - هسته دستگاه انفرادیparaventricular nucleus of the hypothalamus - هسته پروانه مرکزی هیپوتالاموسVit C - ویتامین CPNS - کارمندان دولتReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hypertension is associated to an increase in central oxidative stress and an attenuation of the baroreflex control of arterial pressure. The present study evaluated the effect of alterations in the levels of nitric oxide (NO) and superoxide anion in the caudal ventrolateral medulla (CVLM), a key area of the brainstem for the baroreflex control of arterial pressure, in renovascular hypertensive rats (2K1C). Baseline mean arterial pressure (MAP), heart rate (HR), and reflex bradycardia were evaluated 30Â days after renal artery occlusion in anesthetized (urethane, 1.2Â g/kg, i.p.) 2K1C or normotensive (SHAM) rats. The MAP, HR, and baroreflex control of HR were evaluated before and after CVLM microinjections of the non-selective NOS inhibitor l-NAME (10Â nmol), the NO precursor l-ARG (50Â nmol), or the antioxidant ascorbic acid, Vit C (10Â nmol). In both 2K1C and SHAM animals, CVLM microinjection of l-NAME produced a decrease in MAP, whereas l-ARG induced a significant increase in MAP. However, microinjection of Vit C into the CVLM produced a decrease in MAP and HR only in 2K1C and not in SHAM rats. Cardiovascular effects produced by microinjection of l-ARG into the CVLM were abolished by prior microinjection of l-NAME in the CVLM of 2K1C and SHAM rats. Microinjection of l-NAME into the CVLM increased the sensitivity of reflex bradycardia in 2K1C animals. In contrast, the CVLM microinjection of l-ARG reduced reflex bradycardia only in SHAM rats. Vit C in the CVLM did not change reflex bradycardia in either 2K1C or in SHAM rats. These results suggest that increased oxidative stress in the CVLM during hypertension contributes to the reduced baroreflex sensitivity and to maintain hypertension in the 2K1C model.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nitric Oxide - Volume 26, Issue 2, 15 February 2012, Pages 118-125
Journal: Nitric Oxide - Volume 26, Issue 2, 15 February 2012, Pages 118-125
نویسندگان
Uberdan Guilherme Mendes de Castro, Graziele Galdino de Sousa, Raquel do Pilar Machado, Mauro César Isoldi, Marcelo Eustáquio Silva, Ana Paula Nadu, Luiz Eduardo Sousa, Robson Augusto Souza dos Santos, Maria José Campagnole-Santos,