کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10838855 | 1067181 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Endogenous opioids are necessary for benzodiazepine palatability enhancement: Naltrexone blocks diazepam-induced increase of sucrose-'liking'
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کلمات کلیدی
MesolimbicOpioid - opioidbenzodiazepine - بنزودیازپینAnxiolytic - داروی ضد اضطرابlimbic system - دستگاه کنارهای، سیستم لیمبیکdiazepam - دیازپامBrainstem - ساقه مغزPalatability - طعم و مزهTaste - مزهfood intake - مصرف غذاNaltrexone - نالترکسونNaloxone - نالوکسانHedonic - هدیونیکNucleus accumbens - هسته accumbensparabrachial nucleus - هسته parabrachialReward - پاداشGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Opioid agonists and benzodiazepine agonists each increase food intake. Both also increase hedonic 'liking' reactions to sweet tastes in rats. Do opioids and benzodiazepines share overlapping mechanisms of hedonic impact? Or are benzodiazepine and opioid effects on hedonic impact mediated by independent mechanisms? The present study examined whether blockade of opioid receptors prevents benzodiazepine-induced enhancement of taste palatability, as assessed by the affective taste reactivity test. Rats were implanted with oral cannulae, and prior to an oral infusion of bittersweet quinine-sucrose solution, all received i.p. injections of either vehicle, or diazepam alone (5 mg/kg diazepam + 0 mg/kg naltrexone), naltrexone alone (1 mg/kg naltrexone + 0 mg diazepam), or both diazepam plus naltrexone (5 mg/kg diazepam + 1mg/kg naltrexone). Videotaped hedonic ('liking') and aversive ('disliking') orofacial reactions elicited by sucrose/quinine taste were compared across drug conditions. Diazepam administration alone more than doubled hedonic 'liking' reactions to the bittersweet taste, while reducing 'disliking' in half, compared to vehicle levels. Naltrexone by itself had little effect on taste-elicited affective reactions, and only marginally increased aversive gapes. However, naltrexone completely blocked diazepam's enhancement of positive hedonic 'liking' reactions, and naltrexone similarly disrupted diazepam-reduction of aversive 'disliking' taste reactions. These results indicate that endogenous opioid neurotransmission may be crucial to benzodiazepine enhancement of hedonic 'liking' for natural taste reward.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology Biochemistry and Behavior - Volume 81, Issue 3, July 2005, Pages 657-663
Journal: Pharmacology Biochemistry and Behavior - Volume 81, Issue 3, July 2005, Pages 657-663
نویسندگان
Derek K. Richardson, Sheila M. Reynolds, Steven J. Cooper, Kent C. Berridge,