کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10870945 | 1074027 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MicroRNA profiling during rat ventricular maturation: A role for miR-29a in regulating cardiomyocyte cell cycle re-entry
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کلمات کلیدی
GAPDHCCND2CDK2Cyclin D2MicroRNA-29aUTRProliferation - ترویجpostnatal day 2 - روز بعد از تولد 2microRNAs - ریز آرانایMicroarray - ریزآرایهcyclin-dependent kinase 2 - سیکلین وابسته به کیناز 2Cardiomyocyte - قلب و عروقUntranslated regions - مناطق غیر ترجمهMicroRNA - میکرو RNA MiRNA - میکروRNA، ریزآرانای، miRNAglyceraldehyde-3 phosphate dehydrogenase - گلیسرالیدید-3 فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: MicroRNA profiling during rat ventricular maturation: A role for miR-29a in regulating cardiomyocyte cell cycle re-entry MicroRNA profiling during rat ventricular maturation: A role for miR-29a in regulating cardiomyocyte cell cycle re-entry](/preview/png/10870945.png)
چکیده انگلیسی
Recent studies demonstrated that the mammalian heart possesses some capacity to proliferate. We observed cardiomyocyte proliferation within 4Â weeks of age (P4W) in rats. We found 95 microRNAs that are differentially expressed in P4W cardiomyocytes. MicroRNA-29a was among the most highly up-regulated microRNAs in P4W cardiomyocytes. Overexpression of microRNA-29a suppressed the proliferation of H9c2 cell line. MicroRNA-29a inhibition induced cardiomyocytes to proliferate, accelerated the G1/S and G2/M transition, and up-regulated the cell cycle gene expression. Cyclin D2 (CCND2) was identified as a direct target of microRNA-29a. These findings indicate that microRNA-29a is involved in cardiomyocyte proliferation during postnatal development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 587, Issue 10, 21 May 2013, Pages 1548-1555
Journal: FEBS Letters - Volume 587, Issue 10, 21 May 2013, Pages 1548-1555
نویسندگان
Xiaoqing Cao, Jue Wang, Zhenhua Wang, Juan Du, Xin Yuan, Weicong Huang, Jian Meng, Haiyong Gu, Yu Nie, Bingyang Ji, Shengshou Hu, Zhe Zheng,