Cell signaling pathways involved in hematopoietic stem cell specification

- Generation of hematopoietic stem cells is a pressing goal for regenerative medicine.
- The ontogeny of the hematopoietic system proceeds through multiple waves.
- Hematopoietic stem cell formation requires inputs from multiple cell signaling pathways during embryonic development.
- Current advancements in the generation of hematopoietic stem cells are discussed.