CEACAM1 regulates Fas-mediated apoptosis in Jurkat T-cells via its interaction with β-catenin

► CEACAM1 inhibits Fas-mediated apoptosis. ► Arm-binding motif in CEACAM1 required for this effect. ► CEACAM1 protects beta-catenin from phosphorylation and degradation. ► ITIM of CEACAM1 not involved in Fas-mediated apoptosis. ► Ser-508 involved in regulation of Fas-mediated apoptosis.