کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10904419 | 1086586 | 2012 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Non-apoptotic roles for death-related molecules: When mitochondria chose cell fate
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
The decision between death and survival is a difficult phase of a cell life. It may depend on the intensity of a stress stimulus, on the presence of invasive pathogens, or on specific signals from neighbouring cells. Death-related molecules are being shown to possess different, and sometimes opposite roles, which they play also according to a number of environmental clues. In this review, we will analyse some of these molecules and their roles, with particular regard to mitochondria-related factors, such as BCL2 family members, the apoptosome components, the autophagy/death cross-talkers and molecules regulating mitochondrial structure and functions. Turning the double-edged swords of death molecules into plougshares may turn out to be strategically crucial in molecular oncology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 318, Issue 11, 1 July 2012, Pages 1309-1315
Journal: Experimental Cell Research - Volume 318, Issue 11, 1 July 2012, Pages 1309-1315
نویسندگان
Flavie Strappazzon, Silvia Campello, Francesco Cecconi,