کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10940365 | 1095479 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo
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کلمات کلیدی
Visceral nerveTelencephalonMesencephalonaxon - آکسون tubulin - توبولینDendrite - دندریتdiencephalon - روزمرگیcentral nervous system - سیستم عصبی مرکزیRetina - شبکیهSpinal cord - طناب نخاعیOlfactory nerve - عصب التهابیAdrenal gland - غدد فوق کلیوی، غدههای آدرنالNeural tube - لوله عصبیCerebellum - مخچهBrain - مغزMidbrain - میانمغز، مزانسفالMicrotubules - میکروتوبول، ریزلوله هاneurofilament - نوروفیلامنتNeuron - نورونSensory Neuron - نورون حسیSympathetic neuron - نورون سمپاتیکneocortex - نوقشر، نئوکورتکسHindbrain - هیدروپینProtein - پروتئینEye - چشمMAP kinase - کیناز MAPSensory ganglia - گانگلیس حسیdorsal root ganglia - گانگلیس ریشه پشتیtrigeminal ganglion - گانگلیون سه گانهPelvic ganglion - گانگلیون لگن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
C-Jun N-terminal kinase (JNK) is implicated in regulating the various cellular events during neural development that include differentiation, apoptosis and migration. MUK/DLK/ZPK is a MAP kinase kinase kinase (MAPKKK) enzyme that activates JNK via MAP kinase kinases (MAPKK) such as MKK7. We show here that the expression of MUK/DLK/ZPK protein in the developing mouse embryo is almost totally specific for the neural tissues, including central, peripheral, and autonomic nervous systems. The only obvious exception is the liver, in which the protein is temporally expressed at around E11. The expression becomes obvious in the neurons of the brain and neural crest tissues at embryonic day 10 (E10) after neuron production is initiated. By E14, MUK/DLK/ZPK proteins are found in various neural tissues including the brain, spinal cord, sensory ganglia (such as trigeminal and dorsal root ganglia), and the sympathetic and visceral nerves. The localization of MUK/DLK/ZPK protein in neural cells almost consistently overlapped that of βIII-tubulin, a neuron specific tubulin isoform, and both proteins were more concentrated in axons than in cell bodies and dendrites. The intensely overlapping localization of βIII-tubulin and MUK/DLK/ZPK indicated that this protein kinase is tightly associated with the microtubules of neurons.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene Expression Patterns - Volume 5, Issue 4, April 2005, Pages 517-523
Journal: Gene Expression Patterns - Volume 5, Issue 4, April 2005, Pages 517-523
نویسندگان
Syu-ichi Hirai, Atumi Kawaguchi, Jun Suenaga, Makiko Ono, De Feng Cui, Shigeo Ohno,