کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10962368 | 1102632 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Human CD8+ T cells mediate protective immunity induced by a human malaria vaccine in human immune system mice
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کلمات کلیدی
CSPTCrAAV9Plasmodium yoeliiHuman immune systemAdenovirus - آدنوویروسRecombinant adenovirus - آدنویروس مجددfull-length - تمام طولProtection - حفاظتHIS - خودMalaria - مالاریاCircumsporozoite protein - پروتئین CircumsporozoitePlasmodium falciparum - پلاسمودیوم فالسیپارومT-cell receptor - گیرنده لنفوسیت T
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Human CD8+ T cells mediate protective immunity induced by a human malaria vaccine in human immune system mice Human CD8+ T cells mediate protective immunity induced by a human malaria vaccine in human immune system mice](/preview/png/10962368.png)
چکیده انگلیسی
A number of studies have shown that CD8+ T cells mediate protective anti-malaria immunity in a mouse model. However, whether human CD8+ T cells play a role in protection against malaria remains unknown. We recently established human immune system (HIS) mice harboring functional human CD8+ T cells (HIS-CD8 mice) by transduction with HLA-Aâ0201 and certain human cytokines using recombinant adeno-associated virus-based gene transfer technologies. These HIS-CD8 mice mount a potent, antigen-specific HLA-Aâ0201-restricted human CD8+ T-cell response upon immunization with a recombinant adenovirus expressing a human malaria antigen, the Plasmodium falciparum circumsporozoite protein (PfCSP), termed AdPfCSP. In the present study, we challenged AdPfCSP-immunized HIS-CD8 mice with transgenic Plasmodium berghei sporozoites expressing full-length PfCSP and found that AdPfCSP-immunized (but not naïve) mice were protected against subsequent malaria challenge. The level of the HLA-Aâ0201-restricted, PfCSP-specific human CD8+ T-cell response was closely correlated with the level of malaria protection. Furthermore, depletion of human CD8+ T cells from AdPfCSP-immunized HIS-CD8 mice almost completely abolished the anti-malaria immune response. Taken together, our data show that human CD8+ T cells mediate protective anti-malaria immunity in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 34, Issue 38, 31 August 2016, Pages 4501-4506
Journal: Vaccine - Volume 34, Issue 38, 31 August 2016, Pages 4501-4506
نویسندگان
Xiangming Li, Jing Huang, Min Zhang, Ryota Funakoshi, Dutta Sheetij, Roberta Spaccapelo, Andrea Crisanti, Victor Nussenzweig, Ruth S. Nussenzweig, Moriya Tsuji,