کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10963371 1102680 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rabies vaccine preserved by vaporization is thermostable and immunogenic
ترجمه فارسی عنوان
واکسن باکتریایی که از طریق تبخیر محافظت می شود، بسیار مقاوم و ایمن ساز است
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی
A rabies vaccine that is thermostable over a range of ambient environmental temperatures would be highly advantageous, especially for tropical regions with challenging cold-chain storage where canine rabies remains enzootic resulting in preventable human mortality. Live attenuated rabies virus (RABV) strain ERAG333 (R333E) was preserved by vaporization (PBV) in a dry, stable foam. RABV stabilized using this process remains viable for at least 23 months at 22 °C, 15 months at 37 °C, and 3 h at 80 °C. An antigen capture assay revealed RABV PBV inactivated by irradiation contained similar levels of antigen as a commercial vaccine. Viability and antigen capture testing confirmed that the PBV process stabilized RABV with no significant loss in titer or antigen content. Live attenuated and inactivated RABV PBV both effectively induced RABV neutralizing antibodies and protected mice from peripheral RABV challenge. These results demonstrate that PBV is an efficient method for RABV stabilization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 33, Issue 19, 5 May 2015, Pages 2203-2206
نویسندگان
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