Salmonid alphavirus glycoprotein E2 requires low temperature and E1 for virion formation and induction of protective immunity

Proposed model for low-temperature dependent SAV glycoprotein trafficking. Expression of the (a) SAV envelope cassette and (b) PE2 subunit at 15 °C and expression of the (c) SAV envelope cassette and (d) PE2 subunit at 27 °C. F: furin, cleavage indicated by arrow, ER: endoplasmic reticulum.