کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10964575 | 1102721 | 2015 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
AS03-adjuvanted H7N1 detergent-split virion vaccine is highly immunogenic in unprimed mice and induces cross-reactive antibodies to emerged H7N9 and additional H7 subtypes
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کلمات کلیدی
GMTNIBSCAS03SRIDSingle radial immunodiffusion - ایمونوادفیوس تنها رادیالvirus neutralization - خنثی سازی ویروسNational Institute for Biological Standards and Control - مؤسسه ملی استاندارد و کنترل زیست شناسیhemagglutination inhibition - مهار هموگلوبینgeometric mean titers - میانگین ابعاد هندسیneuraminidase - نورآمینیدازhemagglutinin - هماگلوتینین
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: AS03-adjuvanted H7N1 detergent-split virion vaccine is highly immunogenic in unprimed mice and induces cross-reactive antibodies to emerged H7N9 and additional H7 subtypes AS03-adjuvanted H7N1 detergent-split virion vaccine is highly immunogenic in unprimed mice and induces cross-reactive antibodies to emerged H7N9 and additional H7 subtypes](/preview/png/10964575.png)
چکیده انگلیسی
Avian H7 is one of several influenza A virus subtypes that have the potential to cause pandemics. Herein we describe preclinical results following administration of an investigational H7N1 inactivated detergent-split virion vaccine adjuvanted with the AS03 Adjuvant System. The adjuvanted H7N1 vaccine was highly immunogenic compared to the non-adjuvanted H7N1 vaccine in unprimed mice with less than 100Â ng of hemagglutinin antigen per dose. In addition, compared to the non-adjuvanted vaccine, the AS03-adjuvanted H7N1 vaccine also induced robust HI and VN antibody responses that cross-reacted with other H7 subtypes, including recently emerged H7N9 virus. These H7 data from the preclinical mouse model add to the existing H5 data to suggest that AS03 adjuvant technology may be generally effective for formulating antigen-sparing detergent-split virion vaccines against intrinsically sub-immunogenic avian influenza A virus subtypes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 33, Issue 32, 31 July 2015, Pages 3784-3787
Journal: Vaccine - Volume 33, Issue 32, 31 July 2015, Pages 3784-3787
نویسندگان
Corey P. Mallett, Edith Beaulieu, Marie-Hélène Joly, Benoît Baras, Xiuhua Lu, Feng Liu, Min Z. Levine, Jacqueline M. Katz, Bruce L. Innis, Sandra L. Giannini,