کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10964579 | 1102721 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection
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کلمات کلیدی
CFSEIL-2IL-10PBMCsCBAPhytohemagglutininSSCIL-4FSCIFNγPHAEffector memory cellsHAVInterleukin 17AFBSTNFIL-6LPSFIOCRUZAnti-HAVStrategic Advisory Group of ExpertsDMSO - DMSOcytometric bead array - آرایه مهره سیاتومترInterleukin 10 - اینترلوکین 10interleukin 2 - اینترلوکین 2Interleukin 4 - اینترلوکین 4interleukin 6 - اینترلوکین 6Enzyme-linked immunosorbent assay - تست الیزاELISA - تست الیزاSAGE - حکیمSingle dose - دوز تنهاDimethylsulfoxide - دیمتیل سولفواکسیدWorld Health Organization - سازمان بهداشت جهانیfetal bovine serum - سرم جنین گاوperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیProliferation index - شاخص تکثیرtumor necrosis factor - فاکتور نکروز تومورlipopolysaccharide - لیپوپلی ساکاریدIl-17a - ها The-17hepatitis A vaccine - واکسن هپاتیت Ahepatitis A virus - ویروس هپاتیت ACellular response - پاسخ سلولیforward scatter - پراکندگی رو به جلوside scatter - پراکندگی سمتcarboxyfluorescein succinimidyl ester - کربوکسیفلوورسسین سوکسینیمیدیل استرWHO - کهInterferon gamma - گاما اینترفرون
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection A single dose of inactivated hepatitis A vaccine promotes HAV-specific memory cellular response similar to that induced by a natural infection](/preview/png/10964579.png)
چکیده انگلیسی
Based on current studies on the effects of single dose vaccines on antibody production, Latin American countries have adopted a single dose vaccine program. However, no data are available on the activation of cellular response to a single dose of hepatitis A. Our study investigated the functional reactivity of the memory cell phenotype after hepatitis A virus (HAV) stimulation through administration of the first or second dose of HAV vaccine and compared the response to that of a baseline group to an initial natural infection. Proliferation assays showed that the first vaccine dose induced HAV-specific cellular response; this response was similar to that induced by a second dose or an initial natural infection. Thus, from the first dose to the second dose, increase in the frequencies of classical memory B cells, TCD8 cells, and central memory TCD4 and TCD8 cells were observed. Regarding cytokine production, increased IL-6, IL-10, TNF, and IFNγ levels were observed after vaccination. Our findings suggest that a single dose of HAV vaccine promotes HAV-specific memory cell response similar to that induced by a natural infection. The HAV-specific T cell immunity induced by primary vaccination persisted independently of the protective plasma antibody level. In addition, our results suggest that a single dose immunization system could serve as an alternative strategy for the prevention of hepatitis A in developing countries.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 33, Issue 32, 31 July 2015, Pages 3813-3820
Journal: Vaccine - Volume 33, Issue 32, 31 July 2015, Pages 3813-3820
نویسندگان
Juliana Gil Melgaço, Lucas Nóbrega Morgado, Marta Almeida Santiago, Jaqueline Mendes de Oliveira, Lia Laura Lewis-Ximenez, Bárbara Hasselmann, Oswaldo Gonçalves Cruz, Marcelo Alves Pinto, Claudia Lamarca Vitral,