کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10965429 | 1102748 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Clearance of depot vaccine SPIO-labeled antigen and substrate visualized using MRI
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کلمات کلیدی
SOIROISPIOHPV-16Superparamagnetic iron oxide (SPIO)Site of injectionBSSFPMRI - امآرآی یا تصویرسازی تشدید مغناطیسیSuperparamagnetic iron oxide - اکسید آهن فوقالعاده مغناطیسیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceBalanced steady state free precession - تعصب آزادانه حالت پایدارCancer - سرطانregion of interest - منطقه مورد نظرVaccines - واکسن
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Mice were injected with SPIO-labeled antigen or SPIO-labeled oil, and imaged to examine clearance of labeled components from the vaccine site. The SPIO-antigen was steadily cleared, with nearly half cleared within two months post-vaccination. In contrast, the SPIO-oil remained relatively unchanged. The biodistribution of the SPIO-antigen component within the vaccine site was heterogeneous, indicating the presence of active clearance mechanisms, rather than passive diffusion or drainage. Mice injected with SPIO-antigen also showed MRI contrast for several weeks post-vaccination in the draining inguinal lymph node. These results indicate that MRI can visualize the in vivo longitudinal biodistribution of vaccine components. The sustained clearance is consistent with antigen up-take and trafficking by immune cells, leading to accumulation in the draining lymph node, which corresponds to the sustained immune responses and reduced tumor burden observed in vaccinated mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vaccine - Volume 32, Issue 51, 5 December 2014, Pages 6956-6962
Journal: Vaccine - Volume 32, Issue 51, 5 December 2014, Pages 6956-6962
نویسندگان
Kimberly D. Brewer, Kerry Lake, Nicole Pelot, Marianne M. Stanford, Drew R. DeBay, Andrea Penwell, Genevieve M. Weir, Mohan Karkada, Marc Mansour, Chris V. Bowen,