Plasmodium falciparum synthetic LbL microparticle vaccine elicits protective neutralizing antibody and parasite-specific cellular immune responses

► A synthetic microparticle vaccine elicits protection from malaria in mouse models. ► The vaccine is made using the layer-by-layer (LbL) fabrication method. ► The vaccine includes a peptide subunit of the Plasmodium CS protein. ► All components are chemically synthesized; no biological materials are used.