Oral administration of an adenovirus vector encoding both an avian influenza A hemagglutinin and a TLR3 ligand induces antigen specific granzyme B and IFN-γ T cell responses in humans

► Oral immunization with rAd elicits γ-IFN and granzyme B producing T cells in humans ► Granzyme B responses can be boosted with oral immunization ► Oral immunization with rAd has a positive safety profile ► Oral immunization with rAd does not elicit substantial anti-vector antibody responses.